武汉大学教职工非酒精性脂肪肝病现状及其相关危险因素分析  

Analysis of the Prevalence of Nonalcoholic Fatty Liver Disease and Its Risk Factors in Wuhan University

作　　者：胡卫[1] 杨小铭[2] 

机构地区：[1]武汉大学医院内科,武汉430072 [2]华中科技大学同济医学院附属协和医院感染科,武汉430022

出　　处：《微循环学杂志》2013年第3期40-42,46,I0002,共5页Chinese Journal of Microcirculation

摘　　要：目的:分析武汉大学教职工非酒精性脂肪肝病(NAFLD)的患病现状及相关危险因素。方法:2010年～2011年在武汉大学医院进行体检的该校9094名教职工,通过询问病史、体格检查、生化检查、肝脏彩超检查,按NAFLD诊断标准,将其分为NAFLD组和非脂肪肝组,比较两组的人口学特征及生化指标水平的差异,采用Logistic回归分析NAFLD的危险因素。结果:(1)NAFLD总患病率20.73%,男性患病率(25.88%)高于女性(15.22%)(P<0.01),均在40～59岁年龄段达到峰值;(2)Logistic回归分析显示,NAFLD与体质量指数(BMI)、甘油三酯(TG)、血糖(FBG)、血压、总胆固醇(TC)水平升高显著相关(OR值分别为9.071、3.520、1.899、1.276、1.239,P<0.05或P<0.01),与NAFLD的发生关系最密切的前两位危险因素分别是BMI和TG。结论:该校教职工体检人群NAFLD患病率以40～59岁年龄段发病率最高,BMI、血压、TG、TC、FBG是其危险因素。Objective: To analyze the prevalence of nonalcoholic fatty liver disease among the university folk and to find its risk factors. Method: The survey was conducted among the staff of wuhan university who did health examination from 2010 to 2011 in hospital of wuhan university. The participants had patient history, clinical examination, anthropometry, laboratory tests and routine liver ultrasonography. According to the diagnostic criteria of NAFLD, the cases were divided into two groups, the cases with NAFLD and without NAFLD to compare the demographic characteristics and biochemical indexes of two groups. Then using logistic regression analysis risk factors of nonalcoholic fatty liver patients. Results: The ratio of non-alcoholic fatty liver disease cases was 20.73% ,and the prevalence of nonalcoholic fatty liver disease in males (25.88%) was higher than that in females (15.2%), especially, the highest level was at the age of 40～59.The population with nonalcoholic fatty liver disease had higher levels of FBG, TG ,TC, LDL-C and lower level of HDL-C than those without nonalcoholic fatty liver disease. Logistic regression analysis showed that nonalcoholic fatty liver disease was positively correlated to BMI, TG, FBG,TC, SBP and LDL-C(OR were respectively equal to 9.071,3.520,1.899,1.276,1.239),among which BMI and TG were the two most closely related factors. Conclusion: The prevalence rate of nonalcoholic fatty liver disease in wuhan university was relatively higher, especially at the age of 40～59 which was the same as it in western countries. It is associated with a lot of risk factors, such as BMI,BP,TG,TC,FBG.

关 键 词：非酒精性脂肪肝病 危险因素 

分 类 号：R575[医药卫生—消化系统]