细胞色素P4501A1在子宫颈鳞状细胞癌组织中的表达及其临床意义  

The expression and clinical significance of cytochrome P4501A1 in squamous cell carcinoma

作　　者：石玉荣[1,2] 耿建[1,2] 甘怀勇[3] 章尧[4] 

机构地区：[1]蚌埠医学院生物化学与分子生物学教研室,安徽蚌埠233030 [2]蚌埠医学院检验诊断学实验中心,安徽蚌埠233030 [3]蚌埠医学院病理学教研室,安徽蚌埠233030 [4]皖南医学院生物化学教研室,安徽芜湖241002

出　　处：《蚌埠医学院学报》2013年第8期929-931,共3页Journal of Bengbu Medical College

基　　金：安徽省高等学校青年教师科研资助项目(2008jq1107)

摘　　要：目的:探讨细胞色素P4501A1(cytochrome P4501A1,CYP1A1)在子宫颈鳞状细胞癌(SCC)中的表达及其临床意义。方法:采用免疫组织化学法检测18例正常子宫颈组织、33例子宫颈上皮内瘤变(CIN)组织和124例SCC组织中CYP1A1的表达。分析其表达与SCC的临床病理学参数及预后的关系。结果:CYP1A1在SCC组织中的阳性率(59.7%)高于正常子宫颈组织(11.1%)(P<0.05);在SCC病理分级细胞分化Ⅲ级中CYP1A1的阳性率(69.8%)高于SCC细胞分化Ⅰ级者(34.8%)(P<0.05)。在有淋巴结转移SCC组织中CYP1A1的阳性率(73.6%)高于无淋巴结转移者(49.3%)(P<0.01),CYP1A1表达在SCC的年龄、浸润程度、临床分期和肿瘤大小间差异均无统计学意义(P>0.05)。结论:CYP1A1的高表达可能与SCC的发生、发展等生物学行为有关。Objective： To investigate the expression and clinical significance of cytochrome P4501A1（CYP1A1） in squamous cell carcinoma（SCC）.Methods： The expressions of CYP1A1 in normal cervix tissue（18 cases）,cervical intraepithelial neoplasia（CIN） tissue（33 cases） and SCC tissue（90 cases） were detected by immunohistochemical staining.The relationships between CYP1A1 expression and clinicopathological features and prognosis of cervical cancer were analyzed.Results： The positive expression rate of CYP1A1 in SCC（59.7%） was higher than that in normal cervix（11.1%）（P 0.05）.The positive expression rate of CYP1A1 in stage Ⅲ SCC（69.8%） was obviously higher than that in stageⅠ（34.8%）（P 0.05）.The positive expression rate of CYP1A1 in SCC with lymphnode metastases（73.6%） was higher than that in non-lymphnode metastases（49.3%）（P 0.05）.The expression differences of CYP1A1 in age,depth of invasion,stage and size of tumor had no statistic sigificance（P 0.05）.Conclusions： The high expression of CYP1A1 may be associated with the occurence and development of cervical cancer.

关 键 词：子宫颈肿瘤 细胞色素P4501A1 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]