Bcl-2、CD34在初发性翼状胬肉组织中的表达  

Expression of Bcl-2 and CD34 in pterygium tissue

作　　者：李娟[1,2] 廖荣丰[1] 王剑锋[2] 杨洪霞[2] 

机构地区：[1]安徽医科大学第一附属医院眼科,安徽合肥230022 [2]蚌埠医学院第一附属医院眼科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2013年第8期992-994,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨Bcl-2、CD34在初发性翼状胬肉组织中的表达及翼状胬肉的发病机制。方法:采用免疫组织化学染色(EliVision法)检测Bcl-2、CD34在初发性翼状胬肉患者手术切除标本30例(30眼)和正常球结膜标本5例(5眼)中的表达,并分析其相关性。结果:翼状胬肉头部、颈部、体部组织中Bcl-2和CD34的表达差异均有统计学意义(P<0.01),头部Bcl-2和CD34的表达明显高于颈部和体部组织(P<0.01),而颈部组织CD34表达明显高于体部组织(P<0.01)。结论:Bcl-2、CD34在翼状胬肉头部、颈部、体部均高表达,头部表达最高。提示翼状胬肉头部较其他部位细胞凋亡更少,增殖能力更强,存在过度修复,可能是翼状胬肉发生、发展的机制之一。Objective： To investigate the expression of Bcl-2 and CD34 in the head,neck and body part of the primary pterygium,and to explore the pathogenesis of pterygium.Methods： The expressions of Bcl-2 and CD34 in 30 specimens from patients with primary pterygium and 5 specimens of normal bulbar conjunctiva were detected by immunohistochemical staining（EliVision method）,their correlation was analyzed statistically.Results： The expression of Bcl-2 and CD34 in the head,neck and body part of the pterygium had statistically significant differences（P 0.01）.The expression of Bcl-2 and CD34 was higher in the head part than that in the neck and body part of the pterygium（P 0.01）;the expression of CD34 in the neck part was significantly higher than that in the body part（P 0.01）.Conclusions： Bcl-2 and CD34 express high in the head,neck and body part of the pterygium,and express the highest in the head part.It suggests that the head part of the pterygium has less apoptosis than the other parts;but it is more proliferative and has the probability of excessive repair,which may the pathogenesis of the pterygium.

关 键 词：翼状胬肉 BCL-2 CD34 表达 

分 类 号：R777.33[医药卫生—眼科]