周围型肺癌P16蛋白表达及与CT表现的关系研究  

Correlation Study of P16 Protein Expression and CT Features in Peripheral Pulmonary Carcinoma

作　　者：王云华[1] 李代强 

机构地区：[1]湖南医科大学附属第二医院放射科,长沙410011

出　　处：《临床放射学杂志》2000年第12期799-802,共4页Journal of Clinical Radiology

摘　　要：目的　探讨周围型肺癌中P16蛋白的表达及与CT表现的关系。材料与方法　对 5 7例经手术病理证实的周围型肺癌患者进行胸部CT扫描 ,并应用免疫组化技术SABC法对全部手术切除标本进行P16蛋白检测。结果　肺癌组织中P16蛋白阳性表达率 (5 0 .9% )明显低于癌旁正常肺组织 (93 % ) (P <0 .0 1) ,且同时随肿瘤分化程度的降低而明显降低 (P <0 .0 1)。在CT表现中 ,当肿瘤直径 >3cm ,出现深分叶、棘突征、瘤体邻近胸膜下脂肪线消失或纵隔淋巴结增大者 ,其P16蛋白阳性表达率显著减少 (P <0 .0 1)。结论　P16蛋白表达缺失与周围型肺癌的发生、恶性增殖。Objective To study the significance of P16 gene and the relationship between P16 protein expression and CT findings in peripheral pulmonary carcinoma (PPC).Materials and Methods CT scan was performed in 57 patients with pathologically proved PPC, and the P16 protein expression level of the tumor specimens was estimated with immunohistochemical SABC method.Results P16 protein positive expression rate of PPC specimens was 50.9%, which was significantly lower than that of the adjacent normal lung tissues (P<0.01), and P16 protein expression level bore a parallel relationship to cell differentiation grade of PPC (P<0.01). P16 protein expression rate was extremely low (P<0.01) when PPC demonstrated the following features on CT scans: the diameter of tumor over 3cm, deeply lobulated, spinous process, vanishing of adjacent extrapleural fat line, and mediastinal lymph node enlargement.Conclusion The results indicate that the deletion of P16 protein expression in PPC is linked to the carcinogenesis, progression, differentiation and CT signs.

关 键 词：周围型肺癌 P16蛋白 表现 CT 临床表现 

分 类 号：R734.2[医药卫生—肿瘤]