天智颗粒治疗血管性痴呆的临床观察  

Observation of tianzhi granule in the treatment of vascular dementia

作　　者：白洁[1] 徐亚茹[1] 张艳丽[1] 王瑞龙[1] 

机构地区：[1]齐齐哈尔医学院第一附属医院,黑龙江齐齐哈尔161041

出　　处：《中国当代医药》2013年第23期120-122,共3页China Modern Medicine

基　　金：黑龙江省教育厅科学技术研究面上项目(12521646)

摘　　要：目的研究中药天智颗粒治疗血管性痴呆的效果及其脑保护作用。方法采用回顾性分析方法,根据治疗用药不同将血管性痴呆患者65例分为研究组和对照组,研究组给予中药天智颗粒治疗,对照组使用传统药物奥拉西坦进行治疗,观察两组治疗后认知功能和症状改善情况。结果治疗后,研究组有效率为84.4%,对照组有效率为63.6%,两组比较,差异有统计学意义(P<0.05);治疗后两组定向力、记忆力及计算力均有改善,对应评分升高,组内治疗前后及组间治疗后比较,差异有统计学意义(P<0.05);治疗后研究组日常生活活动(ADL)量表评定效果明显优于对照组(P<0.05),研究组血液流变学指标、红细胞变形和红细胞压积变化明显优于对照组(P<0.05)。结论天智颗粒治疗血管性痴呆,效果良好,可以有效地改善患者的认知功能和脑血管循环,改善脑部缺血缺氧情况,值得临床推广。Objective To study the therapeutic effect of traditional Chinese medicine tianzhi granule in treatment of vascular dementia and its brain protective effect.Methods By retrospective analysis method,65 cases of vascular dementia patients were divided into two groups,the research group and the control group.The treatment of Chinese traditional medicine tianzhi granule was conduct in research group and the treatment of traditional medicine olathe temple was used in control group.After treatment,the cognitive function and symptoms improvement of two groups were observed.Results After treatment,the efficiency of two groups were 84.4% and 63.6% respectively,the difference was significant（P ＆lt;0.05）;after treatment,the directional force,memory and calculation force of two groups were all improved,corresponding score increased,the difference in each group before and after treatment,and the difference between two groups after treatment were all significant（P＆lt;0.05）.At the same time,the ADL effect of research group after treatment were better than control group,and the research group also had a good effect on the blood rheological changes and red blood cell deformation and backlog.Conclusion Tianzhi granule has a good effect on treating vascular dementia,which can effectively improve patients’ cognitive functions and cerebral circulation and perfect brain ischemia hypoxia.It is worthy of promoting on clinic.

关 键 词：天智颗粒 血管性痴呆 脑保护作用 

分 类 号：R749.16[医药卫生—神经病学与精神病学]