E-钙粘蛋白在肿瘤中的作用  

The Role of E-cadherin in Tumor

作　　者：谭米多[1] 黄果[1] 周定耕[1] 刘国文[1] 

机构地区：[1]南华大学第二附属医院,湖南衡阳421001

出　　处：《肿瘤药学》2013年第4期255-258,共4页Anti-Tumor Pharmacy

摘　　要：E-钙粘蛋白是一类细胞表面糖蛋白,在细胞-细胞间粘附中发挥重要作用,参与组织结构的维持。研究表明细胞粘附分子在肿瘤的发生、发展、侵袭和转移中起着重要作用,已成为肿瘤转移分子机制研究的重要课题之一。既往研究认为E-钙粘蛋白是一种肿瘤抑制因子,然而最近研究表明E-钙粘蛋白的异常表达与肿瘤发生、侵袭转移密切相关,提示E-钙粘蛋白不仅有抑癌作用,还具有促癌作用。而肿瘤的侵袭转移是癌症患者死亡的主要原因,本文将对E-钙粘蛋白在肿瘤发生及转移中的作用机制进行综述,以期为肿瘤的临床治疗提供更多的理论依据。E-cadherin is a cell surface glycoprotein. It plays an important role in intercellular adhesion, and participates in the maintenance of the organizational structure. Research results have shown that the cell adhesion molecule has a very important role in tumor development, invasion and metastasis process, and has become one of the important topics in the research of tumor metastasis molecular mechanism. Previous studies suggested that E-cadherin is a tumor suppressor. However, recent studies have shown that the abnormal expression of E-cadherin is closely related with the tumor development, invasion and metastasis, indicating that E-cadherin is not only a tumor suppressor, but also has a role of tumor promotion. Tumor invasion and metastasis is the leading cause of death for cancer patients. Therefore, this paper summarized the role of E-cadherin in tumorigenesis and metastasis mechanism, so as to,provide more theoretical basis for clinical treatment of tumors.

关 键 词：E-钙粘蛋白 肿瘤转移 分子机制 

分 类 号：R730.23[医药卫生—肿瘤]