血清NTx、BSP和PSA检测在前列腺癌骨转移诊断中的意义  

Clinical significance of serum NTx,BSP and PSA in bone metastasis of prostate cancer

作　　者：邓立春[1] 姜藻[2] 沈伟生[1] 盛华明[1] 奚蕾[1] 

机构地区：[1]东南大学医学院附属江阴医院肿瘤科,江苏江阴214431 [2]东南大学附属中大医院肿瘤科,江苏南京210009

出　　处：《现代医学》2013年第8期546-549,共4页Modern Medical Journal

摘　　要：目的:探索前列腺癌患者血清中Ⅰ型胶原氨基末端肽(NTx)、骨唾液酸蛋白(BSP)以及前列腺特异抗原(PSA)的含量与骨转移发生之间的关系。方法:收集73例前列腺癌患者的临床资料,其中骨转移组38例,无骨转移组35例。采用酶联免疫吸附法检测两组患者血清中NTx、BSP和PSA的含量并进行统计分析。结果:骨转移组血清中NTx、BSP的含量明显高于无骨转移组,差异有统计学意义(P<0.05);而骨转移组血清PSA含量与无骨转移组比较,差异无统计学意义(P>0.05);血清NTx含量作为骨转移分子标志的灵敏度达90.0%,特异度为68.6%;血清BSP的灵敏度为84.2%,特异度为71.4%;血清PSA的灵敏度和特异度分别为81.6%和37.1%。结论:前列腺癌患者血清中的NTx和BSP含量对骨转移的发生具有重要的预测意义。Objective： To study the clinical significance of serum pyridinoline cross-linked N-telopeptides of type Ⅰ collagen（NTx）,serum bone sialoprotein（BSP） and serum prostate specific antigen（PSA） in diagnosing bone metastasis of prostate cancer.Methods： 73 patients were divided into 2 groups： bone metastasis group（n = 38） and non-bone metastasis group（n = 35）.The levels of serum NTx,serum BSP and serum PSA were detected by ELISA.Results： The levels of serum NTx and serum BSP in patients with bone metastasis was significantly higher than in those without bone metastasis（P 0.05）,there were no significant differences in serum PSA of the two groups（P 0.05）.The sensitivity and specificity of serum NTx in the diagnosis of bone metastasis were 90.0% and 68.6%,respectively;the sensitivity and specificity of serum BSP were 84.2% and 71.4%,respectively;the sensitivity and specificity of serum PSA were 81.6% and 37.1%.Conclusion： The levels of serum NTx and BSP are important biomarkers for the diagnosis of bone metastasis prostate cancer.

关 键 词：Ⅰ型胶原氨基末端肽 骨唾液酸蛋白 前列腺特异抗原 骨转移 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]