大肠癌病人胃泌素和生长抑素的检测及其临床意义  

The Clinical Significance of Gastrin and Somatostatin in Patients with Colon Cancer

作　　者：程宝平[1] 王爱玲[1] 朱存如[1] 梁红梅 

机构地区：[1]安徽医科大学第一附属医院,合肥230022

出　　处：《临床消化病杂志》2000年第5期213-214,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的 :研究胃泌素和生长抑素含量的变化及其对大肠癌的临床意义。方法 :用放射免疫分析法测定了 43例大肠癌病人的空腹血清胃泌素 (SG)和生长抑素 (SS) ,并对不同临床分期、不同病理类型、手术前后SG和SS水平进行了比较。结果 :发现空腹血清胃泌素DukesCD期显著高于DukesAB期 ,即随着病程的进展逐渐升高 ;相反生长抑素降低。并提示它们升高或降低的程度同癌肿浸润和扩散的程度有关。而不同病理组织学型之间血清胃泌素 /生长抑素浓度无显著性差异。根治性大肠癌切除术后血清胃泌素含量较术前明显下降 ;相反生长抑素升高。而姑息性手术后血清胃泌素 /生长抑素则无变化。结论 :血清胃泌素 /生长抑素含量的测定 ,可能作为大肠癌预后判断的一个参考指标。大肠癌病人空腹血SG/SS水平可作为操纵激素做内分泌治疗的理论依据。空腹血胃泌素和生长抑素水平可作为选择大肠癌病人进行内分泌治疗的临床指标之一。Purpose: To study the clinical significance and somatostatin in patients with colon cancer. Methods: Serum gastrin and somatostatin of 43 cases with colon cancer was determined with radioimminoassay and the difference between various clinical stages, different kinds of pathology, before and behind operation were compared. Results: The serum gastrin in stage C and D(based on Dukes standards) is significantly higher than that in stage A and B, while the serum somatostatin appered an opposition tendency. It suggested that the degrees of increase about serum gastrin and the decrease of serum somatostatin was related to the degree of infiltration and spread of colon cancer, but no difference was found between different kinds of pathology. There was significant decrease of serum gastrin and increase of the serum somatostatin after radical colonectomy, but no difference was found after conservative operation. Conclusion: The level of somatostatin should be used as a reference in predicting the prognosis of colon cancer. The determination of the serum gastrin and somatostatin in patients with colon cancer may be an effective method in operating endocrine treatment with somatostatin

关 键 词：大肠癌 胃泌素 生长抑素 根治性切除术 治疗 

分 类 号：R735.3[医药卫生—肿瘤]