125I粒子治疗复发脑胶质瘤疗效及对环境辐射观察  

Clinical observation of 125I seed treatment of recurrence of glioma and the environmental radiation

作　　者：施立海[1] 张楠[1] 左峰[1] 

机构地区：[1]首都医科大学附属北京安贞医院神经外科 ,北京市100029

出　　处：《中国基层医药》2013年第19期2900-2902,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察125I粒子治疗复发脑胶质瘤的治疗效果及环境辐射情况。方法64例复发性脑胶质瘤患者，根据其患者及家属的意愿分为观察组30例和对照组34例，比较两组临床治疗效果，并随访125I粒子对周围辐射的影响。结果观察组近期治疗有效率60．0％（18／30），对照组治疗有效率35．3％（12／34），两组差异有统计学意义（x2=8．39，P〈0．05）。随访0—6个月，周围环境辐射随着与植入点的距离增加而迅速衰竭，距离为40cm时测得辐射剂量已经接近天然基础辐射剂量；而且125I粒子测得辐射剂量也随着植入后时间的增加而不断衰减，4个月后已经接近天然基础辐射剂量。结论125I放射性粒子治疗复发性脑胶质瘤近期疗效良好，对周围环境的辐射影响易于防护。Objective To observe 125I seed treatment effect and environmental radiation in the treatment of recurrent glioma. Methods 64 patients with recurrent glioma patients, according to the wishes of patients and their families were divided into observation group of 30 cases and a control group of 34 patients. Clinical outcomes and fol- low-up of 1251 seeds around radiation were compared between the two groups. Results The treatment efficiency of ob- servation group and control group was 60.0% （18/30） ,and 35.3% （12/34） ,respectively,which was statistically sig- nificant （x2 = 8.39, P 〈 0.05 ）. Follow-up from 0 to 6 months, the ambient radiation rapidly decreased as the distance increaseing with the implantation point, radiation dose in a distance of 40cm has been close to the natural basis of ra- diation dose;125I seeds measured radiation dose continued to decay with increasing time after implantation. Four months later,it was close to the natural basis of radiation dose. Conclusion Conclusion 125I radioactive particles in the treatment of recurrent glioma have good curative effect. The effects of radiation on the surrounding environment crowd are easily protected.

关 键 词：碘放射性同位素 脑胶质细胞瘤 

分 类 号：R739.4[医药卫生—肿瘤]