前列腺疾患与前列腺癌发病关系的病例-对照研究  

Case control Study on the Relationship Between Prostate Cancer and History of Prostatic Diseases

作　　者：安宁 庞维秋[2] 刘言训[2] 

机构地区：[1]济南市卫生防疫站,山东济南250013 [2]山东医科大学卫生统计学教研室,山东济南250012

出　　处：《中国慢性病预防与控制》2000年第5期214-215,共2页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：山东省自然科学基金资助 !(Y97C12 0 48)

摘　　要：目的 :探讨既往前列腺疾患对前列腺癌发病的影响。方法 :于 1997～ 1999年间对济南五大医院中经病理组织学确诊的 96例前列腺癌新发病例实施 1∶ 3配比的病例 -对照研究。三类对照共计 2 88例 (其中医院癌对照、医院非癌对照、正常对照各 96例 )。配比条件为同性别、同民族、年龄相近 (相差不超过± 5岁 )。结果 :经条件 L ogistic回归分析 ,结果显示 :前列腺癌病例与三类对照比较 ,既往前列腺疾患 (前列腺炎及前列腺良性增生 )可能增加患前列腺癌的危险性 ,两种疾患在三类对照中的 OR值分别为 7.82、9.83、7.0 0及 6 .71、7.0 0、8.42 ,P值均小于 0 .0 0 1。结论Objective:In order to evaluate the correlation of prostate diseases to prostate cancer.Methods:A hospital based case control study was conducted in 5 hospitals in Jinan.There were 96 cases with histopathologically confirmed prostate cancer between 1997~1999. 288 controls,including 96 of other cancer inpatients,96 non cancer inpatients and 96 neighborhood controls,were individually matched to the cases by sex,age,and nationality(case control ratio=1∶3).Results:With Logistic regression analysis,prostatitis and benign prostatic hyperplasia(BPH) were significantly related to prostate cancer.Compared with groups of other cancer cases,non cancer cases and neighborhood controls,the Odds Ratio( OR ) of prostatitis was 7 82,9 83,7 00( P <0 001),the OR of BPH was 6 71,7 00,8 42( P <0 001) respectively.Conclusions:It concluded that history of prostatitis and BPH might be higher risk factors for prostate cancer.

关 键 词：前列腺癌 前列腺炎 病例对照研究 

分 类 号：R737.250.2[医药卫生—肿瘤]