A General and Highly Selective Method for the Asymmetric Synthesis of Trifluoromethyl-Substituted α- and β-Aminophosphonates  

作　　者：Lijing Wang Qilong Shen Long Lu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2013年第7期892-900,共9页中国化学（英文版）

基　　金：Acknowledgement The authors gratefully acknowledge the financial support from National Basic Research Program of China （Nos. 2012CB821600, 2010CB126103）, the Key Program of the National Natural Science Foundation of China （No. 21032006）, National Natural Science Foun- dation of China （Nos. 21172244/21172245/B020304）, Agro-scientific Research in the Public Interest （No. 201103007）, the National Key Technologies R＆D Pro- gram （No. 2011BAE06B05）, and Shanghai Scientific Research Program （No. 10XD 1405200）.

摘　　要：A highly selective method for the asymmetric formation of trifluoromethyl-substituted α- and β-aminophos- phonates was described. The reaction proceeded with high yields and good to excellent diastereoselectivity. The product can be easily converted into corresponding trifluoromethyl-substituted aminophosphoric acids.A highly selective method for the asymmetric formation of trifluoromethyl-substituted α- and β-aminophos- phonates was described. The reaction proceeded with high yields and good to excellent diastereoselectivity. The product can be easily converted into corresponding trifluoromethyl-substituted aminophosphoric acids.

关 键 词：TRIFLUOROMETHYL AMINOPHOSPHONATE ASYMMETRIC FLUORINE 

分 类 号：O621.34[理学—有机化学] O633.5[理学—化学]