奥氮平治疗首发精神分裂症的疗效及其对认知功能的影响  

Influences of olanzapine on curative effects and congnitive function of first-episode schizophrenics

作　　者：梅尚英[1] 徐文军[1] 吴海波[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《国际医药卫生导报》2013年第18期2882-2885,共4页International Medicine and Health Guidance News

摘　　要：目的探讨奥氮平治疗首发精神分裂症患者的疗效及其对认知功能的影响。方法对91例首发精神分裂症患者给予口服奥氮平治疗，观察8周。治疗前后采用阳性与阴性症状量表（PANSS）评定临床疗效，采用威斯康星卡片分类测验（WCST）及韦氏成人记忆量表（WMS）的数字广度、数字符号、再生分量表评定患者的认知功能。结果治疗8周后，痊愈29例，显著进步35例，进步21例，无效6例，总有效率93．4％。PANSS及认知功能均有明显改善，不良反应轻微。结论奥氮平治疗精神分裂症疗效显著、安全性高、依从性好，又能改善患者的认知功能。Objective To explore the influence of olanzapine on curative effects and congnitive function of patients with first-episode schizophrenics. Methods 91 first-episode schizophrenics were treated with olanzapine orally for 8 weeks, and assessed with curative effects by Positive and Negative Syndrome （PANSS）, and cognitive functions with the Wechsler Memeory Scale（WMS） and Wisconsin Card Sorting Test （WCST） before and after treatment. Results Compared with pretreatment, at the end of 8-week treatment, both negative and positive symptoms of all subjects improved significantly, adverse reactions were mild, scores of the PANSS lowered more significantly （P〈0.01）; first-episode schizophrenics acted better in the WCST and WMS （P〈0.01）. Conclusion Olanzapine has an evident effect, higher safety and better compliance, and meanwhile it can improve patients＇ congnitive function.

关 键 词：首发精神分裂症 认知功能 奥氮平 

分 类 号：R749.3[医药卫生—神经病学与精神病学]