缺陷型精神分裂症患者认知功能的研究  

Research of cognitive function in deficit schizophrenia

作　　者：唐小伟[1,2] 耿德勤[1] 沙维伟 张晓斌 周朝昀 

机构地区：[1]徐州医学院研究生学院,江苏徐州221002 [2]江苏省扬州五台山医院,江苏扬州225003

出　　处：《实用临床医药杂志》2013年第11期59-61,共3页Journal of Clinical Medicine in Practice

基　　金：江苏省"六大人才高峰"第8批次资助(2011-WS076)

摘　　要：目的探讨缺陷型精神分裂症患者认知功能的变化。方法采用Stroop测验、连线测试(TMT)、范畴流利测验对35例缺陷型精神分裂症、61例非缺陷型精神分裂症、59例健康志愿者进行测评。结果缺陷型、非缺陷型精神分裂症组的所有神经心理测验均差于正常对照组(P<0.05)。缺陷型精神分裂症除Stroop色词测验外,其他的神经心理测验成绩与非缺陷型精神分裂症相比差异均有统计学意义[分别为(122.53±69.05),(318.30±203.74),(45.49±21.74),(28.86±12.95),(14.37±5.06),(P<0.05)]。除Stroop色词测验外,SDS阴性症状分、SANS量表分与其他神经心理测验均呈显著相关(P<0.05或0.01)。结论精神分裂症存在广泛的认知功能损害,而缺陷型精神分裂症作为一种独立亚型,可能存在更严重的额叶损伤。Objective To explore the change of cognitive function in deficit schizophrenia.Methods Stroop Test,Trail Making Test（TMT）,Category Fluency Test were administered in 35 patients with deficit schizophrenia,61 patients with non-deficit schizophrenia,and 59 healthy controls.Results Deficit and non-deficit schizophrenia showed dysfunction in neuropsychological tests compared with controls（P〈0.05）.Deficit schizophrenia showed significant differences in other neuropsychological tests compared with nondeficit schizophrenia except Stroop color-word Test [（122.53±69.05）,（318.30±203.74）,（45.49±21.74）,（28.86±12.95）,（14.37±5.06）,P〈0.05].The scores of SDS negative symptoms and SANS measuring scale were significantly correlated with other neuropsychological tests except Stroop color-word Test（P〈0.05 or 0.01）.Conclusion There are wide cognitive impairment in schizophrenia.And deficit schizophrenia may have more severe damage in frontal lobe as an independent hypotype.

关 键 词：精神分裂症 缺陷型 精神分裂症 非缺陷型 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]