mFOLFOX6方案与CapeOX方案治疗老年转移性结直肠癌临床疗效分析  

Clinical effects of mFOLFOX6 and CapeOX regimens for senile metastatic colorectal cancer

作　　者：周慧俊[1] 殷先利[1] 刘振洋[1] 李勇[1] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院消化泌尿内科,湖南长沙410013

出　　处：《实用临床医药杂志》2013年第13期33-36,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321006)

摘　　要：目的观察mFOLFOX6方案与CapeOX方案治疗老年转移性结直肠癌的临床疗效及不良反应。方法将168例发生转移的老年结直肠癌患者随机分为2组,mFOLFOX6组82例接受奥沙利铂＋亚叶酸钙＋5-氟尿嘧啶治疗,CapeOX组86例接受奥沙利铂＋卡培他滨治疗。2组均至少治疗2个周期。比较2组临床疗效及不良反应。结果 2组总有效率、中位疾病进展时间及中位生存期无显著差异。2组不良反应主要包括口腔黏膜炎、神经毒性、腹泻、恶心呕吐、白细胞减少、中性粒细胞减少和转氨酶升高,且以Ⅰ~Ⅱ度为主。mFOLFOX6组Ⅲ~Ⅳ度中性粒细胞减少率显著高于CapeOX组,但CapeOX组手足综合征发生率显著高于mFOLFOX6组。结论 mFOLFOX6方案与CapeOX方案治疗老年转移性结直肠癌疗效相当,且不良反应均能耐受,但CapeOX方案用药更方便,更适合体质较弱的老年患者或门诊接受化疗的患者。Objective To observe the clinical effects and adverse reactions of mFOLFOX6 regimen as well as CapeOX in the treatment of senile metastatic colorectal cancer.Methods One hundred and eight-six patients with senile metastatic colorectal cancer were randomly divided into two groups.Eight-two cases in mFOLFOX6 group were treated with oxaliplatin＋calcium folinatc＋5-fluorouracil,while another 86 in CapeOX group with oxaliplatin＋capecitabine.Both groups were treated for at least two weeks.The clinical effects and adverse reactions in two groups were compared.Results There were no significant differences compared with the total effectiveness rate,medial time to progression and medial survival time of two groups.The adverse reactions of two groups mainly included oral mucositis,neurotoxicity,diarrhea,nausea,vomiting,leucopenia,neutropenia and elevated transaminase,primarily at Ⅰ-Ⅱ grades.Neutropenia rate at Ⅲ-Ⅳ grades in mFOLFOX6 group was obviously higher than CapeOX group,but the incidence of hand-foot syndrome in CapeOX group was markedly higher than that in mFOLFOX6 group.Conclusion The therapeutic effects of mFOLFOX6 and CapeOX regimens are equal,and both adverse reactions are tolerable.However,the administration of CapeOX regimen is simpler,more suitable for the senile patients with weak constitution or receiving chemotherapy in the outpatient.

关 键 词：5-氟尿嘧啶 亚叶酸钙 奥沙利铂 卡培他滨 老年 转移性结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]