依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用及血清TNF-α水平的影响  

Therapeutic effects of edaravone on postoperative encephaledema due to intracranial tumors treated with γ-knife and its influences on level of serum TNF-α

作　　者：龙超[1] 贺少枫[1] 郭健[1] 陈平[1] 

机构地区：[1]解放军102医院内科,江苏常州213003

出　　处：《实用临床医药杂志》2013年第14期11-13,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321067)

摘　　要：目的探讨依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用。方法 78例颅内肿瘤经γ-刀放射治疗患者,随机分为治疗组(n=40)和对照组(n=38)。所有患者治疗期间纠正电解质紊乱,对照组给予甘露醇、地塞米松磷酸钠治疗;治疗组在对照组基础上给予依达拉奉。观察2组临床疗效及不良反应发生情况、治疗前后血清TNF-α水平变化。结果治疗组总有效率为92.5%,对照组总有效率为68.4%,治疗组总有效率明显高于对照组。2组不良反应发生率比较无显著差异。2组治疗前(入院次日)血清TNF-α水平无显著差异;治疗14 d后2组血清TNF-α水平均较治疗前明显下降,治疗组下降更加明显。结论依达拉奉对颅内肿瘤刀术后脑水肿疗效明显该治疗作用可能与降低血清水平有关。Objective To investigate the therapeutic effects of edaravone on postoperative encephaledema due to intracranial tumors treated with γ-knife.Methods Seventy-eight patients with intracranial tumors treated withγ-knife radiation were randomly divided into treatment group （n =40） and control group （n =38）.Electrolyte disturbances in all patients were corrected during treatment.The control group was treated with mannitol and dexamethasone sodium phosphate,while the treatment group was added edaravone based on the treatment of the control group.The clinical effects,incidence of adverse reactions and levels of serum tumor necrosis factor-α （TNF-α） before and after treatment were observed in both groups.Results The total effectiveness rate of the treatment group （92.5％） was significantly higher than that of the control group （68.4％）.There was no significant difference between the incidences of adverse reactions in both groups.The statistical significance was not presented regarding the levels of serum TNF-α in both groups before treatment （the next day of hospitalization）,whereas 14 d after treatment,the levels of serum TNF -α in 2 groups decreased obviously compared with those before treatment,and the decreased range of treatment group was larger.Conclusion Edaravone has notable therapeutic effects on postoperative encephaledema due to intracranial tumors treated with γ-knife,which may be associated with the decrease of serum TNF-α.

关 键 词：依达拉奉 颅内肿瘤 脑水肿 肿瘤坏死因子-α 

分 类 号：R739.41[医药卫生—肿瘤]