埃索美拉唑联合铝碳酸镁治疗胃食管反流病的临床疗效  

Clinical therapeutic effect of esomeprazol combined with hydrotalcite on gastroesophageal reflux disease

作　　者：周海川[1] 谢崇凡[1] 吴启斌[1] 

机构地区：[1]重庆市梁平县人民医院内一科,重庆梁平405200

出　　处：《实用临床医药杂志》2013年第16期65-67,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨埃索美拉唑联合铝碳酸镁治疗胃食管反流病(GERD)的临床疗效。方法将2010年1月—2012年8月本院诊治的GERD患者130例随机分组,每组各65例,观察组给予埃索美拉唑联合铝碳酸镁,对照组仅给予铝碳酸镁。治疗6周,比较2组患者治疗前后临床症状发作频率及症状严重程度及临床疗效。结果 2组治疗6周后计分较治疗前均显著降低(P<0.01),且观察组计分降低程度明显高于对照组,差异均有统计学意义(P<0.01);对照组总有效率为77.59%(50/65),观察组总有效率为92.3%(60/65),观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论埃索美拉唑联合铝碳酸镁是一种安全、高效治疗GERD的方法,值得临床推广应用。Objective To study the clinical therapeutic effect of esomeprazol combined with hydrotalcite on gastroesophageal reflux disease （GERD）.Methods One hundred and thirty patients with GERD from January 2010 to August 2012 were divided into two groups randomly,65 in each group.The observation group was treated with esomeprazol combined with hydrotalcite,and the control group was treated with hydrotalcite only.After six weeks of treatment,the frequency of clinical symptoms and the severity of symptoms and the clinical effect of the two groups were compared.Results The frequency of clinical symptoms and the severity of symptoms were significantly lower in the two group 6 weeks after the treatment than before treatment,and lowering degree of scoring of the observation group was higher than that of the control group （P＜0.01）.In comparison with the control group,total efficacy rate in the observation group was significantly higher （P＜0.05）.Conclusion Esomeprazol combined with hydrotalcite is a safe and efficient treatment method of GERD,and it is worthy of clinical complication.

关 键 词：埃索美拉唑 铝碳酸镁 胃食管反流病 

分 类 号：R573[医药卫生—消化系统]