多药耐药因子在胃癌中表达的相关性及其临床意义  

Expression correlations and clinical significance of multidrug resistance factors in gastric cancer

作　　者：蔡丽芳 肖琳琳 吴宁 胡宇 黄伟明 

机构地区：[1]福建省莆田市第一医院肿瘤内科,福建莆田351100

出　　处：《实用临床医药杂志》2013年第15期8-10,共3页Journal of Clinical Medicine in Practice

摘　　要：目的研究多药耐药因子在胃癌中表达的相关性及其临床意义。方法采用免疫组化检测64例胃癌手术切除标本的P-糖蛋白(P-gp)、p53、谷胱甘肽S转移酶-π(GST-π),并探讨与胃癌的病理类型、病灶直径、TNM分期、淋巴结转移、2年无病生存时间的相关性。结果 P-gp、p53和GST-π在胃癌组织的表达率分别为75.0%、65.6%和68.8%。P-gp与淋巴结转移情况呈正相关;中晚期和有淋巴结转移的胃癌p53表达显著高于早期和淋巴结未转移者;GST-π表达随着分化程度增高而增加。p53和P-gp之间呈正相关性。p53和P-gp共同表达生存率显著低于阴性者。结论 P-gp、p53和GST-π是胃癌生物学行为的重要指标,联合检测P-gp和p53对于判定胃癌预后具有重要意义。Objective To investigate the expression correlation and clinical significance of multidrug resistance factors in gastric cancer. Methods Immunohistochemistry was applied to detect P-glycoprotein （P-gp）, p53 and glutathione S-transferase-π（GST-π） of resected specimens of 64 patients with gastric cancer performed the operation, and the correlations with pathological pat- terns, lesions diameter, TNM staging, lymph node metastasis and 2-year-disease-free survival of gastric cancer were explored. Results The expression rates of P-gp, p53 and GST-π in tissue of gastric cancer were 75.0 %, 65.6 % and 68.8 % respectively. P-gp had a positive correlation with lymph node metastasis, p53 expression of gastric cancer at middle advanced stage and with lymph node metastasis was distinctly higher than that of early stage and those without lymph node metastasis. GST-π expression increased with the increase of differentiated degrees. There was a positive correlation between p53 and P-gp, and their common expression survival rates were markedly lower than those of negative ones. Conclusion P-gp, p53 and GST-π are important indicators of biological behavior of gastric cancer, and the joint detection of P-gp and p53 is of great significance for the prognosis of gastric cancer.

关 键 词：P-糖蛋白 P53 谷胱甘肽S转移酶-Π 胃癌 多药耐药 

分 类 号：R735.2[医药卫生—肿瘤]