广泛性焦虑患者单胺递质、神经内分泌及免疫的动态观察  

A longitudinal study of monoamine neurotransmitters, neuroendocrine and immune parameter in the patients with generalized anxiety disorder

作　　者：张亚林[1] 赵靖平[1] 杨德森[1] 卢晓红 张向晖 曹玉萍[1] 

机构地区：[1]湖南医科大学附属第二医院精神卫生研究所,长沙410011

出　　处：《中华精神科杂志》2000年第4期200-202,共3页Chinese Journal of Psychiatry

基　　金：国家自然科学基金资助项目! ( 3 95 70 2 69)

摘　　要：目的　探讨广泛性焦虑患者于中国道家认知疗法治疗前后的血浆肾上腺素 (EPH)、去甲肾上腺素 (NE)、促肾上腺皮质激素 (ACTH)、皮质醇 (CS)和白细胞介素Ⅱ (IL 2 )水平的动态变化。方法　收集 2 9例患者接受中国道家认知疗法治疗 6个月 ,于治疗前后取血测定上述生化指标 ,选择2 9名年龄和性别相匹配的正常人作为对照组。结果　患者组治疗前EPH为 (5 91± 34 5 )ng/L、ACTH为 (2 4± 2 1)ng/L ,IL 2为 (2 2 3± 2 0 1)U/L ,均高于对照组 [(35 2± 10 9)ng/L、(12± 11)ng/L、(88± 86 )U/L],差异有显著性 (P <0 0 5 ) ;CS为 (79± 49)U/L ,低于对照组 (138± 74)U/L ,差异有显著性 (P <0 0 5 ) ;NE为 (741± 390 )ng/L ,与对照组 (75 1± 2 11)ng/L的差异无显著性 (P >0 0 5 )。患者经 6个月治疗焦虑症状缓解后 ,ACTH [(14± 9)ng/L]和IL 2 [(133± 76 )U/L]水平较治疗前降低 (P <0 0 5 ) ,CS[(148± 10 7)U/L]水平增高 (P <0 0 5 ) ,均接近于对照组水平 (P >0 0 5 )。结论　广泛性焦虑患者存在生化指标EPH、ACTH、CS和IL 2的异常 ,中国道家认知疗法可使患者的临床症状缓解、生化指标恢复正常。Objective To investigate plasma epinephrine (EPH), norepinephrine (NE), adrenocor ticotropin (ACTH),cortisol and interleukin 2 (IL 2) levels of generalized anxiety disorder (GAD) in baseline and post treatment of Chinese Taoist Psychotherapy (CTCP), a longitudinal study was conducted Methods 29 patients with GAD who had received 6 months CTCP and 29 normal controls matched by sex and age were enrolled in the study The biochemical parameters were measured before and after the treatment Results The baseline levels of EPH, ACTH and IL 2 in the patients with GAD patients were (591±345) ng/L, (24±21) ng/L and (223±201) U/L respectively, significantly higher than that of the controls ( P <0 05), and cortisol level was (79±49) U/L, significantly lower than that of the controls (P<0 01) After improvement of anxiety symptoms,the levels of EPH,ACTH and IL 2 significantly decreased and cortisol significantly increased,which were equal to that of the controls Conclusions It indicates that the levels of EPH, ACTH, cortisol and IL 2 are abnormal in the patients with GAD, which can recover with the improvement of anxiety symptoms

关 键 词：焦虑症 生物胺神经递质类 氢化可的松 IL-2 

分 类 号：R749.720.2[医药卫生—神经病学与精神病学]