5-羟色胺6受体基因多态性与抑郁症的关联研究  

An association study of the 5-HT_6 receptor gene in major depression

作　　者：王立伟[1] 江三多[2] 汪栋祥[2] 钱伊萍[2] 顾牛范[1] 

机构地区：[1]复旦大学华山临床医学院精神病学教研室,上海200040 [2]上海市精神卫生研究所分子遗传学研究室

出　　处：《中华精神科杂志》2000年第4期216-217,共2页Chinese Journal of Psychiatry

摘　　要：目的　探讨 5 羟色胺 6 (5 HT6)受体基因多态性与抑郁症之间的关系。方法　应用聚合酶链反应 (PCR)和限制性片段长度多态性 (RFLP)技术 ,对 89例抑郁症患者 (抑郁症组 )和 90名正常对照者 (对照组 )的 5 HT6受体基因多态性 (2 6 7C/T)进行了检测。结果　 5 HT6受体基因的 3种基因型(C/C ,C/T和T/T)在抑郁症组中的分布分别为 5 8%、37%和 5 % ,在对照组分别为 45 %、48%和 7% ,两组间差异无显著性 (χ2 =3.0 14,P >0 .0 5 )。结论　 5 HT6受体基因的 2 6 7C/T多态性与抑郁症之间无显著性关联。Objective The purpose of this study was to investigate the association between 5 HT 6 receptor gene polymorphism and major depression. Methods The genotypes and allelic frequencies of the 5 HT 6 receptor gene were examined with polymerase chain reaction and restriction fragment length polymorphism techniques in 89 patients with major depression and 90 unrelated healthy controls. Results The genotype (C/C, C/T and T/T) distribution of the 267C/T polymorphism of the 5 HT 6 receptor gene in patients was 58%, 37% and 5% respectively, and 45%, 48%, 7% in controls respectively. No significant difference was found between the patients and controls(χ 2=3.014, P>0.05). Conclusion The results suggested that the 267C/T polymorphism of the 5 HT 6 receptor gene was not significantly associated with major depression.

关 键 词：抑郁症 5-羟色胺6受体 基因多态性 

分 类 号：R749.410.2[医药卫生—神经病学与精神病学]