川芎嗪对兔高眼压视神经轴突损伤保护作用的研究  

The protective effect of ligustrazine on optic nerve axons in rabbit eyes with continuous elevated IOP

作　　者：李兴英[1] 杨连洲[1] 康凤英[1] 张士胜[1] 李公宝[2] 韩月香[3] 翟玉梅[1] 

机构地区：[1]山东省潍坊医学院附属医院眼科,261031 [2]山东省潍坊医学院附属医院中心实验室,261031 [3]山东省潍坊医学院附属医院药剂室,261031

出　　处：《中华眼科杂志》2000年第6期442-444,I029,共4页Chinese Journal of Ophthalmology

摘　　要：目的　探讨川芎嗪对兔持续性高眼压视神经轴突损伤的保护作用。方法　对 36只新西兰白兔眼前房注入α 糜蛋白酶 ,制作成持续性高眼压模型后 ,随机等分为高眼压对照组和川芎嗪治疗组 ,治疗组于高眼压持续 7d始肌注川芎嗪 ,观察不同时间两组动物球结膜微循环变化及视神经轴突光、电镜结构改变。结果　与高眼压对照组相比 ,川芎嗪组结膜微循环障碍明显减轻 (P <0 0 1) ,视神经轴突数目多、直径小 ,占视神经面积百分比高 (P <0 0 1) ,且肿胀的视神经轴突结构基本正常。结论　川芎嗪可通过改善微循环状况 ,对兔高眼压视神经轴突起保护作用。Objective To investigate the effects of ligustrazine on optic nerve axons in rabbit eyes with continuous elevated intraocular pressure (IOP). Method Thirty-six NZ rabbits with continuous elevated IOP induced by injection of α-chymotrypsin into anterior chamber were divided into two groups by randomization: treatment and control group. Ten mg/kg ligustrazine injected into the treatment group every day for 3 weeks began on the 7 th day after IOP elevated continuously. The changes of conjunctival microcirculation and optic nerve axonal ultrastructure were observed at different time points. Results The destruction of conjunctival microcirculation and axonal ultrastructure was milder in treatment group than that in the control group. In addition, the total number of axons and the percentage of axons in optic nerve area were higher, whereas the axonal diameter was smaller in the treatment group. Conclusion It is suggested that ligustrazine protect optic nerve axons from more damage induced by elevated IOP through improving ocular microcirculation.

关 键 词：川芎嗪 高眼压 视神经轴突损伤 动物实验 

分 类 号：R775.06[医药卫生—眼科] R774.605[医药卫生—临床医学]