白斑脱落粘膜上皮细胞与组织上皮细胞微核率相关性分析  

The correlation analysis between frequency of micronucleated cells of exfoliated oral mucosa cells and oral mucosa cells in different grading of oral leukoplakia lesions

作　　者：孙正[1] 李宁[2] 张中仪[1] 沈胜利[1] 

机构地区：[1]首都医科大学附属北京口腔医院口腔内科,100050 [2]中国预防医学科学院营养与食品卫生研究所

出　　处：《中华口腔医学杂志》2000年第6期439-441,共3页Chinese Journal of Stomatology

摘　　要：目的　检测口腔白斑患者脱落粘膜细胞微核细胞率及相应组织细胞微核细胞率 ,并进行相关性分析 ,为将该项指标应用于口腔白斑的治疗和判断预后提供依据。方法　采用Feuglen染色方法 ,对 5 9例单纯增生、32例轻和中度异常增生性白斑及 2 8例重度异常增生性白斑和口腔鳞癌患者的口腔脱落粘膜细胞和组织上皮细胞微核进行了检测 ,同时检测了 10 0例健康人的口腔脱落粘膜细胞微核作为正常对照。结果　口腔白斑患者脱落粘膜细胞微核细胞率明显高于对照组 ,且随着病变程度的加重微核细胞率也增高 ,与病变程度呈正相关 (r=0 .9997,P <0 .0 0 1)。各病变组口腔粘膜脱落细胞与组织细胞微核细胞率显著相关。结论　口腔脱落粘膜细胞微核细胞率可反映组织病变程度 ,可作为白斑辅助诊断和预测其转归的指标 。Objective To provide evidence for using micronucleated cells of exfoliated oral mucosa cells in diagnosis and treatment of oral leukoplakias and chemopreventive studies of oral cancer. Methods Micronuclei of exfoliated oral mucosa cells and oral mucosa cells in 119 patients comprising 59 simple hyperplasia,32 mild and moderate oral leukoplakia and 28 severe oral leukoplakia and oral squamous carcinoma by Feulgen stain method were examined , and micronuclei of exfoliated oral mucosa cells in 100 normal persons were also examined.Results Frequency of micronucleated cells of exfoliated oral mucosa cells in oral leukoplakia lesions was higher than that of normal persons. Frequency of micronucleated cells of exfoliated oral mucosa cells had a positive correlation with oral leukoplakia lesions( r =0.999 7, P < 0.001) and with frequency of micronucleated cells of oral mucosa cells ( P <0.001). Conclusions Frequency of micronucleated cells of exfoliated oral mucosa cells are useful markers to the clinician to predict oral leukoplakia behaviour and prognosis and substitute for frequency of micronucleated cells of oral mucosa cells as intermediate endpoint in chemopreventive trials.

关 键 词：口腔粘膜白斑病 口腔肿瘤 微核 上皮细胞 

分 类 号：R781.590.2[医药卫生—口腔医学]