应力环境影响双侧卵巢切除大鼠下颌骨骨量变化的研究  

The effects of local stress on bone mass of mandibles in ovariectomized rats

作　　者：周永胜[1] 周书敏[1] 李国珍[1] 薛延[2] 

机构地区：[1]北京医科大学口腔医学院修复科,100081 [2]京市积水潭医院创伤骨科研究所

出　　处：《中华口腔医学杂志》2000年第6期470-473,共4页Chinese Journal of Stomatology

摘　　要：目的　观察双侧卵巢切除 (去势 ) (ovariectomy ,OVX)大鼠下颌骨应力环境改变与下颌骨骨量的关系。方法　拔除大鼠右侧上颌全部磨牙 ,使咀嚼侧 (左 )、非咀嚼侧 (右 )下颌骨分别处于相对的高低应力环境中 ;利用去势手术 (OVX)模仿绝经后骨质疏松症 (postmenopausalosteoporosis)。依此将48只雌性大鼠分为 4组 :①OVX +拔牙组 ,②OVX +非拔牙组 ,③Sham OVX(假去势 ) +拔牙组 ,③Sham OVX +非拔牙组。在实验 1.5个月和 3个月时应用单光子骨密度仪对各组大鼠下颌骨双侧进行骨密度测量。结果　去势大鼠下颌骨骨量显著低于正常对照组大鼠 (P <0 .0 5 )。对于正常大鼠 ,在拔牙 3个月时 ,低应力侧下颌骨骨量显著低于高应力侧 (P <0 .0 5 ) ,但它们与非拔牙对照组的差异均无显著性。对于去势大鼠 ,低应力侧下颌骨骨量显著低于高应力侧 (P <0 .0 1) ,在 3个月时 ,低应力侧骨量显著低于OVX同期对照组 (P <0 .0 5 ) ,而高应力侧下颌骨骨量显著高于OVX同期对照组 (P <0 0 5 ) ,但与Sham OVX同期对照组比 ,仍显著偏低 (P <0 .0 5 )。结论　咀嚼功能可减缓雌激素低下所引起的下颌骨快速骨丢失 ,对于保持下颌骨骨量有一定的作用 ;而咀嚼功能低下或缺失则加重其骨丢失进程。因此 ,对于有骨质疏松症的患者 ,应尽早恢复?Objective To observe the relationship between the change of stress environment of mandibles and their bone mass in normal and ovariectomized(OVX) rats. Methods The high and low stress environment models of mandibles were established by unilateral maxillary molars extraction. The masticatory sides of the mandibles were regarded as the high stress sides and the non masticatory sides were regarded as the low stress sides. Ovariectomized rats were utilized as postmenopausal osteoporosis models and Sham ovariectomized(Sham OVX) rats as control group. According to these ideas, 48 female rats were divided into 4 groups: 1)OVX+extraction group; 2)OVX+non extraction group; 3)Sham OVX+extraction group; 4)Sham OVX+non extraction group. The bone mineral densities(BMD) of all mandibles were measured by single photon absorptiometry bilaterally 1.5 months and 3 months after extraction. Results The mandibles of ovariectomized rats had lower BMD than those of normal rats( P <0.05). To normal rats, the BMD of mandibles in low stress sides were lower than the high stress sides 3 months after extraction( P <0.05), but the BMD of the two sides were not significantly different to those of the non extraction control ones( P >0.05). To ovariectomized rats, the BMD of mandibles low stress sides were much lower than the high stress sides( P <0.01). The BMD of mandibles in low stress sides were much lower than non extraction ones of OVX group after 3 months( P <0.05). The BMD of the high stress sides were much higher than those of the non extraction control ones of OVX group( P <0.05), but they were still lower than those of the non extraction control ones of Sham OVX group( P <0.05). Conclusion The results indicate that the masticatory functions(the high stress environment) tend to conserve the mandibular bone mass in patients with systemic osteopenia such as postmenopausal osteoporosis and the masticatory deficiency(the low stress environment) tends to aggravate mandibular bone loss induced by sy

关 键 词：应力 骨质疏松 骨密度 卵巢切除术 下颌骨 

分 类 号：R782.13[医药卫生—口腔医学] R711.750.6[医药卫生—临床医学]