细胞因子对视网膜变性疾病防治作用的研究进展  

Progression in the research of cytokine mediated protective effects on retinal degeneration

作　　者：姚慧萍[1] 丁慰祖[1] 

机构地区：[1]上海市第八人民医院眼科,200235

出　　处：《临床眼科杂志》2013年第4期373-377,共5页Journal of Clinical Ophthalmology

摘　　要：视网膜变性疾病是严重的致盲性眼病,感光细胞的凋亡是其主要表现。细胞因子是机体组织细胞合成和分泌的小分子多肽类因子,参与多种细胞生理功能的调节,减少细胞的凋亡。随着对各种细胞因子,特别是神经营养因子作用机理的不断阐明,越来越多的研究发现外源性的给予或内源性的诱发其表达,对于变性视网膜光感受器的保护是有积极作用的。本文将近年来用于视网膜变性疾病方面研究的神经营养因子和部分非神经营养因子类细胞因子,包括神经生长因子、睫状神经营养因子、脑源性神经生长因子、碱性成纤维生长因子、神经营养因子-3、促红细胞生成素等作一综述。Retinal degeneration is a serious disabling ophthalmopathy.Apoptosis of the photoreceptor cells is the main pathological mechanism.Cytokine,a kind of polypeptides that are synthesized and secreted by histiocytes,has been known to involve in the homeostatic accommodation of cells,and play a role in prevention cells from apoptosis.More and more studies pointed that exogenous or endogenous increase of cytokines has a protective effect on photoreceptor degeneration.This paper reviewed some neurotrophic factors and other popularly studied cytokines,including nerve growth factor,cilliary neurotrophic factor,brain-derived neurotrophic factor,basic fibroblast growth factor,neurotrophin-3,and erythropoietin.

关 键 词：视网膜变性 神经营养因子 细胞因子 神经生长因子 睫状神经营养因子 脑源性神经生长因子 碱性成纤维生长因子 神经营养因子-3 

分 类 号：R774.1[医药卫生—眼科]