短暂性脑缺血发作与IL6、IL8和IL10的关系  

Relationship between TIA and IL6,IL8 and IL10

作　　者：陈蓓蕾 李晓波 李军 马莉 

机构地区：[1]扬州市苏北人民医院神经内科,江苏225009

出　　处：《脑与神经疾病杂志》2013年第4期247-250,共4页Journal of Brain and Nervous Diseases

基　　金：扬州市科技局资助项目(YZ2011102);江苏省卫生厅资助项目(YZ201021)

摘　　要：目的探讨IL6、IL8及IL10和短暂性脑缺血发作(TIA)患者颈动脉斑块稳定性与疾病预后的关系。方法根据颈动脉CTA检查将TIA患者分为不稳定性斑块组和稳定性斑块组,比较两组患者血清IL6、IL8及IL10水平的差异;检测健康对照组血清IL6、IL8及IL10水平,并与TIA患者组比较;根据TIA患者的预后分为痊愈组、反复发作组、进展为脑梗死组,比较三组患者间血清IL6、IL8及IL10水平的差异。结果不稳定性斑块组患者血清IL6、IL8水平明显高于稳定性斑块组,血清IL10水平低于稳定性斑块组。TIA患者血清IL6、IL8及IL10水平均高于健康对照组。进展为脑梗死组、反复发作组患者的血清IL6、IL8及IL10水平均高于痊愈组。结论血清IL6、IL8水平与颈动脉斑块的稳定性呈负相关,而血清IL10水平与颈动脉斑块的稳定性呈正相关。血清IL6、IL8及IL10水平高的TIA患者易进展为脑梗死。Objective To investigate the correlation of serum interleukin-6（IL6）,interleukin-8（IL8） and interleukin-10（IL10） to the stability of carotid plaques and the prognosis of transient ischemic attacks（TIA）.Methods Divided TIA patients into two groups based on the result of computed tomography angiograph（CTA） and compare the serum IL6,IL8 and IL10 levels of the stable plaque group and instable plaque group.Detected the serum IL6,IL8 and IL10 levels of control group and compare to those of TIA patients.Divided TIA patients into three groups based on the prognosis and compare the serum IL6,IL8 and IL10 levels among cure group,recurrent attack group and cerebral infarction group.Results The serum IL6 and IL8 levels of instable plaque group were much higher than those of stable plaque group while the IL10 levels were just the reverse.The serum IL6,IL8 and IL10 levels of TIA patients were much higher than those of control groups and those of the recurrent attack group and cerebral infarction group were higher than the levels of cure group.Conclusion The serum IL6 and IL8 levels have negative correlation to the stability of carotid plaques while the IL10 levels are just the reverse.Those who have high serum IL6,IL8 and IL10 levels are more likely round into cerebral infarction.

关 键 词：白介素6 白介素8 白介素10 短暂性脑缺血发作 

分 类 号：R743.31[医药卫生—神经病学与精神病学]