微波消解-ICP/MS法测定替曲朵辛中的13种微量金属元素  

Determination of 13 metalelements in Tetrodotoxin by microwave digestion and ICP/MS

作　　者：代秀梅[1,2] 于风平 张启明[2] 王瑾[2] 

机构地区：[1]山东省淄博市食品药品检验所,淄博255086 [2]中国食品药品检定研究院,北京100050

出　　处：《药物分析杂志》2013年第8期1382-1384,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:建立替曲朵辛中金属元素的测定方法。方法:采用微波消解-ICP/MS法测定替曲朵辛中的Al、Mn、Ni、As、Pb、V、Fe、Cu、Cd、Cr、Co、Zn和Ba共13种金属元素。结果:方法检出限为0.03～1.5×10-9g.g-1,牛肝标准物质加标回收率在85%～109%,各元素线性关系良好。结论:微波消解-ICP/MS法用量少、检出限低、分析速度快、能同时分析替曲朵辛中多种元素。Objective： To establish a method for determination of heavy metal elements in tetrodotoxin.Methods： ICP / MS was used to determine 13 metal elements in tetrodotoxin,including Al,Mn,Ni,As,Pb,V,Fe,Cu,Cd,Cr,Co,Zn and Ba.Results： The method detection limits for all target elements were with a range of 0.03-1.5 × 10-9 g.g-1,while the recovery values ranged from 85% to 109%.The correlation coefficients were good.Conclusion： The microwave digestion-ICP / MS method has a low detection limit,a fast analysis rate and it only requires a small amount of sample which can simultaneously analyze various elements in tetrodotoxin.

关 键 词：ICP MS 替曲朵辛 微波消解 金属元素 铝 锰 镍 砷 铅 钒 铁 铜 镉 铬 钴 锌 钡 

分 类 号：R917[医药卫生—药物分析学]