微乳技术对止痛凝胶膏剂中成分释放和含量变化的影响  

Effect of microemulsion technology on release of compounds in Zhitong cataplasm and content variation

作　　者：李学敏[1] 王琼[1] 兰颐[1] 安静[1] 王文平[1] 赵博琛[1] 吴清[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2013年第16期2614-2617,共4页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2012CB724001);国家高技术研究发展计划(863)项目(2009AA043201);北京市自然基金项目(7132127);北京中医药大学复方中药制药研究创新团队项目(2011-CXTD-13)

摘　　要：该文考察了凝胶膏中黏合剂的种类,用单因素法考察了凝胶膏剂成型时所需加入的黏合剂的用量,并以黏性和黏性的评分作为指标考察了凝胶膏的载药量,确定了止痛微乳凝胶膏的成型方法。采用改良Franz扩散池法,以欧前胡素和阿魏酸为指标性成分考察了止痛凝胶膏剂中水溶性成分和脂溶性成分的释放,结果显示微乳型止痛凝胶膏对欧前胡素和阿魏酸的释放有促进作用。最后利用HPLC检测到止痛微乳凝胶膏中挥发性成分损失量较原止痛凝胶膏降低了23.13%。试验最终制备了微乳凝胶膏的成品,发现微乳技术有助于促进处方中脂溶性成分和水溶性成分的同步释放,并能减少挥发性成分的损失。To study the varieties of adhesives in gels on the basis of previous studies, dosage of adhesives required for forming of gels by using the single factor design, as well as the drug loading capacity of gels with the adhesiveness and stickiness as the scoring indicators, in order to determine the forming method of analgesic micro-emulsion gel. Subsequently, the improved Franz diffusing cell method was adopted to study the release of water-soluble components and liposoluble components in analgesic gels, with imperatorin and ferulic acid as index components. The results showed that analgesic micro-emulsion gel could promote the release of imperatorin and ferulic acid. Finally, HPLC was used to detect that the loss amount of volatile components in analgesic micro-emulsion gel was 23.13% lower than that in the original analgesic gel. In the experiment, we finally prepared finished products of micro-emulsion gel, discovered that the micro-emulsion technology is helpful to improve the synchronous release of water-soluble components and liposoluble components in prescriptions and can reduce the loss of volatile components.

关 键 词：微乳 凝胶膏剂 同步释放 挥发性成分 

分 类 号：R283[医药卫生—中药学]