国产乙肝基因工程疫苗免疫持久性研究  

Researches in the Immunogenicity and the Immune Persistence of the Domestic Recombinant Hepatitis B Vaccine

作　　者：杨超美[1] 李天舒[1] 曾义学[1] 白红[1] 陈丹林[1] 向真 陈益[2] 梁争论[3] 

机构地区：[1]四川省卫生防疫站,成都610031 [2]自贡市卫生防疫站 [3]中国药品生物制品检定所

出　　处：《预防医学情报杂志》2000年第3期193-194,共2页Journal of Preventive Medicine Information

摘　　要：目的　国产乙肝基因疫苗应用时间不长 ,其免疫持久性尚不清楚。为评价国产乙肝CHO疫苗的免疫效果和免疫持久性而进行本研究。方法　应用两批国产乙肝CHO疫苗 (长春生物制品研究所生产 ) ,10 μg/剂。按 0、 1、 6程序免疫 15 0名HBVm阴性儿童 ,免疫后随访观察 5 6月。结果　全部接种儿童均无局部和全身异常反应。T7时抗—HBs阳转率均为 10 0 % ,T56时阳转率分别为 88 5 7%和 78 5 7%。Objective The aim of this study is to evaluate the immunogenicity and the immune persistence of domestic product of Chinese hamster ovary cell derived recombnant hepatitis B vaccine(CHO vaccine).Methods Two batches of CHO vaccine (10μg/dose)were administered to 150 children aged 6 to 11 with HBV mark negative.The immune regment was 0、1 and 6 months.Results No severs adverse reaction was found in all the children.The anti-HBs positive conversion rate were 100% 7 months after the first injection.The rate were 88.57% and 78.57% respectively At 56th months.Conclusion The results revealed that the safety and the immunogenicity of CHO vaccine is good.

关 键 词：乙肝基因疫苗 免疫效果 免疫持久性 

分 类 号：R512.620.3[医药卫生—内科学] R979.5[医药卫生—临床医学]