立体定向丘脑腹外侧核毁损治疗帕金森病  

Stereotatic posteroventral lateral thalamotomy for the treatment of Parkinson's disease

作　　者：曾凡俊[1] 陈礼刚 黄茂清[1] 曾力[1] 李开慧[1] 匡永勤[1] 李讯[1] 

机构地区：[1]成都军区总医院,610083

出　　处：《四川医学》2000年第9期769-770,共2页Sichuan Medical Journal

摘　　要：目的　探讨影响立体定向丘脑腹外侧核毁损术治疗帕金森病疗效的因素。方法　分析 16年来采用立体定向丘脑腹外侧核毁损术治疗帕金森病的影像学改变及影响疗效的因素分析 ,并将 1990年以前与以后的资料进行比较。结果　本组病例症状完全控制 95 0例 (74.2 1% ) ,症状控制伴有肢体麻木、情感、智能障碍 2 70例 (2 1.0 9% ) ,无效 5 0例(3.9% ) ,恶化 10例 (0 .78% )。结论　 CT定位靶点法与脑室造影定位法对疗效影响无显著差异 ,而靶点定位、毁损大小与手术疗效及并发症密切相关。Objective To evaluate the effect of stereotatic posteroventral lateral thalamotomy for Parkinsons disease(PD).Methods 1280 patients with PD unerwent stereotatic posteroventral lateral thalamotomy in the past 16 years.These cases were retrospectively analysed,including the CT or MRI findings and the influential factors of the surgical result.The clinical data of th patients before 1990 were compared with those thereafter.Results The treatment for the 1280 cases achieved marked improvement in 950(74.21%) cases and brought to some improvement in 270 (21.09%)cases Ineffectiveness was observed in 50(3.9%)patients,and aggravation of symptoms was noted in 10(0.78%) patients.Conclusion There was no statistically significant difference between CT localization method and ventriculography localization method in regard to the surgical results,nevertheless the degree of accurate localization and the size of destroyed target were closely related with the surgical outcome and postoperative complications.

关 键 词：帕金森病 丘脑毁损术 立体定向外科 

分 类 号：R742.5[医药卫生—神经病学与精神病学]