New Crystalline Forms of Mebendazole with n-Alkyl Carboxylic Acids Neutral and Ionic Status  

作　　者：Jiamei Chen Tongbu Lu 

机构地区：[1]School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China [2]MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/State Key Laboratory of OptoelectronicMaterials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China

出　　处：《Chinese Journal of Chemistry》2013年第5期635-640,共6页中国化学（英文版）

摘　　要：Structural information on the crystalline forms of mebendazole, an anti-parasitic drug, is limited, although three polymorphic forms of this drug have been reported. The present work investigates the structures and properties of different crystalline forms of mebendazole with a series of n-alkyl carboxylic acids, including trifluroacetic acid （1）, formic acid （2）, acetic acid （3）, propanoic acid （4）, butanoic acid （5）, valeric acid （6） and hexanoic acid （7）. These compounds were characterized by thermogravimetric analysis, IR spectra, as well as powder and single-crystal X-ray diffraction analysis. The R22（8） structural motif was detected in all the seven products, which was formed by a pair of N--H…O/O--H…N hydrogen bonds between mebendazole and carboxylic acid. Forms 3--7 were found to be neutral solvate, while in forms 1 and 2, proton transfer was observed from carboxylic acid to mebendazole.Structural information on the crystalline forms of mebendazole, an anti-parasitic drug, is limited, although three polymorphic forms of this drug have been reported. The present work investigates the structures and properties of different crystalline forms of mebendazole with a series of n-alkyl carboxylic acids, including trifluroacetic acid （1）, formic acid （2）, acetic acid （3）, propanoic acid （4）, butanoic acid （5）, valeric acid （6） and hexanoic acid （7）. These compounds were characterized by thermogravimetric analysis, IR spectra, as well as powder and single-crystal X-ray diffraction analysis. The R22（8） structural motif was detected in all the seven products, which was formed by a pair of N--H…O/O--H…N hydrogen bonds between mebendazole and carboxylic acid. Forms 3--7 were found to be neutral solvate, while in forms 1 and 2, proton transfer was observed from carboxylic acid to mebendazole.

关 键 词：crystal engineering hydrogen bond supramolecular synthon crystalline form MEBENDAZOLE 

分 类 号：TQ132.32[化学工程—无机化工] S943.223[农业科学—水产养殖]