白细胞介素-1B多态性与神经胶质瘤的关联  

Association between interleukin-1B polymorphisms and risk of glioma

作　　者：岩亮[1] 舒云[2] 

机构地区：[1]云南省西双版纳州人民医院外四科,云南景洪666100 [2]云南省西双版纳州人民医院普通外科,云南景洪666100

出　　处：《国际神经病学神经外科学杂志》2013年第3期204-207,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨白细胞介素-1B(IL-1B)多态性与神经胶质瘤的相关性。方法采用聚合酶链反应-限制性片段长度多态性检测152例神经胶质瘤患者和201例正常对照组IL-1B-511C/T和-31T/C多态性。结果 IL-1B-511C/T位点:与CC基因型相比,TT基因型显著增加了神经胶质瘤的发病风险(χ2=5.61,P=0.021)。与C等位基因相比,T等位基因显著增加了神经胶质瘤的发病风险(χ2=5.71,P=0.019)。未发现IL-1 B-31 T/C多态性频率分布在对照组和神经胶质瘤组之间存在明显差异。IL-1B-511C/T和-31T/C两位点单倍型分析显示,-511C/-31T单倍型显著降低了神经胶质瘤的发病风险(χ2=4.89,P=0.03),-511 T/-31 C单倍型显著增加了神经胶质瘤的发病风险(χ2=18.55,P<0.001)。结论 IL-1B可能是中国人群神经胶质瘤发病的易感基因。Objective To investigate the association between interleukin-1B（IL-1B） polymorphisms and risk of glioma.Methods The IL-1B-511C/T and-31T/C polymorphisms were detected in 152 patients with glioma and 201 healthy controls using polymerase chain reaction-restriction fragment length polymorphism analysis.Results The TT genotype at position-511C/T in the promoter region of IL-1B was associated with a significantly increased risk of glioma compared with the CC genotype（χ2=5.61,P=0.021）.Similarly,the T allele at position-511C/T was associated with a significantly increased risk of glioma compared with the C allele（χ2 =5.71,P=0.019）.There was no significant difference in the frequency distribution of IL-1B-31T/C polymorphism between cases and controls.Results from haplotype analysis showed that the-511C/-31T haplotype was associated with a significantly decreased risk of glioma（χ2 =4.89,P=0.03）;conversely,the-511T/-31C haplotype was associated with a significantly increased risk of glioma（χ2 =18.55,P＆lt;0.001）.Conclusions IL-1B may be a susceptibility gene for the development of glioma in Chinese population.

关 键 词：白细胞介素1B 多态性 神经胶质瘤 

分 类 号：R739.4[医药卫生—肿瘤]