消化道混合性腺神经内分泌癌9例病理形态观察  

Pathomorphologic Observation of 9 Cases with Gastrointestinal Mixed Adeneuroend ocrine Carcinoma of Digestive System

作　　者：申健[1] 达小萍[1] 葛丽艳[1] 

机构地区：[1]天津大港油田总医院病理科,天津300280

出　　处：《临床消化病杂志》2013年第4期196-197,200,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的分析消化道混合性腺神经内分泌癌的病理形态特征,探讨其诊断要点。方法对确诊为混合性腺神经内分泌癌的消化道手术切除标本9例进行光镜观察和突触素(Syn)、嗜铬粒蛋白(CgA)、癌胚抗原(CEA),细胞角蛋白8/18(CK8/18),Ki-67等5种抗体免疫组织化学染色,并复习其临床资料.结果镜下可见具有腺癌特征和神经内分泌肿瘤特征的两种区域,各种标志物的免疫组化染色阳性比率:CEA及CK8/18全部阳性(9/9,100%),Syn阳性6例(6/9,66.7%),CgA阳性5例(5/9,55.6%)。结论消化道混合性腺神经内分泌癌临床上比较少见,形态学上与常见的低分化腺癌不易区分,需要依靠免疫组化检测进行区分,其预后较一般腺癌差。Objective To analyse the pathomorphology of gastrointestinal mixed adeneuroendocrine carcinoma of digestive system and to investigate the main points of diagnosis. Methods The pathologic features of 9 cases were observed, all of them immunoehemieally stained with Syn, CgA, CEA, CK8/18, Ki-67, and viewed their clinical data in all. Results The mor- phological types of the tumors have differentiated two distinct tumors which are adenoearcinoma and neuroendocrine neoplasm. Immunohistochemically,the expression rates of markers was 100% for CEA and CK8/18,66.7% for Syn and 55.6% for CgA. Conclusion As a rare type tumor of digestive system, mixed adencuroendocrine carcinoma is a newly described entity. More attention should be paid in the daily practice in order to differentiated the tumor from poor differentiated adenocarcinoma. The immunohistoehemieal examination is important to the diagnosis. The progeosis of the tumor is poorer than ordinary adenoearcino- ma,

关 键 词：混合性腺神经内分泌癌 消化道 免疫组织化学 病理学观察 

分 类 号：R735[医药卫生—肿瘤]