异甘草酸镁与复方甘草酸苷治疗慢性肝炎的疗效比较  

Comparison of the Efficacy of Magnesium lsoglycyrrhizinate and Compound GlycyrrhizinInjection in the Treatment of Chronic Hepatitis

作　　者：王崇慧[1] 郑三菊[1] 占国清[1] 

机构地区：[1]湖北医药学院附属人民医院肝病科,十堰442000

出　　处：《临床消化病杂志》2013年第4期203-205,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的比较异甘草酸镁与复方甘草酸苷治疗各种慢性肝炎的临床疗效和安全性。方法 115例慢性肝炎患者被随机分为治疗组(54例)和对照组(61例)。两组均对病因进行综合治疗。治疗组给予异甘草酸镁注射液150 mg加入5%葡萄糖液250 ml中静脉滴注,每日1次;对照组给予复方甘草酸苷160 mg加入5%葡萄糖液250 ml静脉滴注,每日1次。疗程均为4周。观察两组患者治疗前后症状(乏力、纳差、腹胀及肝区不适)、肝功能(AST、ALT、TBIL、PA)等指标变化及药物不良反应。结果治疗后两组患者症状均明显改善,组间比较差异无统汁学意义(P>0.05);治疗后2周及4周,与对照组比较,治疗组AST、ALT明显降低(P<0.01),PA明显升高(P<0.05,P<0.01);治疗组和对照组的有效率分别为96.3%和82.0%,差异有统计学意义(χ2=5.87,P<0.05);治疗组的不良反应少于对照组。结论与复方甘草酸苷比较,异甘草酸镁治疗各种慢性肝炎的疗效和安全性更好。Objective To compare the clinical efficacy and security of magnesium isoglycyrrhlzlnate and compound gly- cyrrhizin injection in the treatment of chronic hepatitis. Methods 115 cases of chronic hepatitis were randomly divided into the treatment group （n --54 ）and the control group （n = 6 I）. The two groups were given therapy on the etiology. The treatment group were treated with 150 mug magnesium isoglycyrrhizinate injection and the control group were treated with 160 mg compound gly- cyrrhizin injection once daily for 4 weeks. Symptoms （ fatigue, anorexia, abdominal distention, liver area unwell ） , liver function （AST, ALT, TBIL, PA）change and drug adverse reactions were observed before and after treatment. Results The patients＇ symptoms were improved significantly after treatment,there were no statistically significant difference between the two groups（P 〉 0.05 ）. After treatment 2 weeks and 4 weeks, compared with control group, the treatment group AST, ALT decreased signifi- cantly（P 〈 0.01 ）,PA increased significantly （P 〈 0.05, P 〈 0.01 ）. The effective rates of treatment group and control group were 96.3% and 82.0% respectively,there was significant difference between the two groups（ X2 = 5.87,P 〈 0.05）. Adverse reactions were less in treatment group than control group. Conclusion Compared with compound glycyrrhizin, magnesium iso- glycyrrhizinate has better curative effect and security in the treatment of chronic hepatitis.

关 键 词：慢性肝炎 异甘草酸镁 复方甘草酸昔 疗效 

分 类 号：R575.1[医药卫生—消化系统]