老年口腔鳞状细胞癌细胞凋亡相关基因蛋白的表达及分析  

Experssion and Analysis of Apoptosis-Related Gene Products in the Tissue of Old Pral Sqsuamous Cacinoma

作　　者：郭玲玲[1] 盛江筠[2] 张永格 李红[1] 

机构地区：[1]山东医科大学附属医院病理科,济南市250012 [2]山东医科大学口腔医院,济南市250012 [3]河北省衡水卫校,衡水市053000

出　　处：《肿瘤防治杂志》2000年第4期353-355,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :探讨老年口腔鳞状细胞癌组织细胞凋亡相关基因蛋白表达及其与临床病理特征的关系。方法 :采用微波处理LSAB法 ,分析 62例老年口腔鳞癌手术切除石蜡包埋组织中细胞凋亡相关基因bcl 2、bax和p53蛋白表达情况。另取正常老年人口腔粘膜做对照。结果 :bcl 2阳性率 4 8 38% ,在分化程度高者高表达 ,且与淋巴结转移呈负相关 (P <0 0 5) ;p53阳性率为 32 2 6% ,多见于中、低分化和有淋巴结转移的患者 (P <0 0 5) ;bax的表达在不同分化及淋巴结转移方面未显示有统计学差异。结论 :表明细胞凋亡相关基因bcl 2。Objective:To evaluate the expression pattern of apoptosisrelated factors and compare the expression with clinicopathological findings in senile oral squamous carcinoma (OSC).Methods:62 cases of senile OSC were examined by using immunohistochemistry.Results:bcl2 stainning was detected in 48.38% senile OSC.p53 expression was linked with high histological grade and found in 32.26% senile OSC.Conclusions:Poptosisrelated factors bcl2 and p53 were involved in some biological behaviour of senile OSC and they may play an important role in the development of senile OSC.

关 键 词：口腔疾病 鳞状细胞癌 癌基因 免疫组织化学 

分 类 号：R739.85[医药卫生—肿瘤]