SASH1基因在食管鳞癌中的表达及临床意义  

Clinical significance of expression of SASH1 in esophageal squamous cell carcinoma

作　　者：刘秋菊[1] 贺远龙[1] 刘红云[2] 卫红军[2] 许琳[1] 王青[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院消化科,山东省青岛市266071 [2]青岛大学医学院附属青岛市市立医院病理科,山东省青岛市266071

出　　处：《世界华人消化杂志》2013年第22期2198-2201,共4页World Chinese Journal of Digestology

基　　金：国家自然科学基金青年科学基金资助项目;No.81101813~~

摘　　要：目的:探讨候选抑癌基因SASH1在食管鳞状细胞癌中的表达及与肿瘤相关的临床病理特征的关系.方法:应用免疫组织化学SP法检测72例食管鳞癌组织及40例癌旁组织中SASH1蛋白的表达.结果:SASH1蛋白在癌组织阳性表达率显著低于癌旁组织,统计学分析表明两者差异有显著意义(41.67%vs80.00%,P<0.001).其表达率在食管鳞癌伴淋巴结转移组中较不伴淋巴结转移组明显降低(2=6.583,P<0.05).其在食管鳞癌组织中的表达水平与肿瘤分化程度及TNM分期相关(P<0.05).结论:SASH1基因在食管鳞癌中表达下调,该基因可能是食管鳞癌的肿瘤抑制基因,可能作为分子标记而用于食管鳞癌的诊断和治疗.AIM：To detect the expression of SAM-and SH3domain containing 1（SASH1） in human esophageal squamous cell carcinoma（ESCC）,and to analyze the relationship between SASH1 expression and clinical and pathological parameters of ESCC.METHODS：The expression of SASH1 was detected by immunohistochemistry in 72 ESCC specimens and 40 tumor-adjacent specimens.RESULTS：The positive rate of SASH1 protein expression in ESCC was significantly lower than that in tumor-adjacent non-carcinoma tissue（41.67% vs 80.00%,P 0.001）.The positive rate of SASH1 protein expression was significantly higher in patients without lymph node metastasis than in those with lymph node metastasis（2 = 6.583,P 0.05）.Expression of SASH1 was associated with tumor differentiation and TNM stage in ESCC（both P 0.05）.CONCLUSION：Down-regulation of SASH1 expression occurs in ESCC.SASH1 may be a novel tumor suppressor in ESCC and can be used as a molecular maker for the diagnosis and treatment of ESCC.

关 键 词：食管鳞癌 SASH1基因 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]