固态核磁共振及其在药物晶型研究中的应用  

Solid-state nuclear magnetic resonance and its application in research of drug polymorphs

作　　者：陈立亚[1] 赵慧芳[1] 

机构地区：[1]中国食品药品检定研究院,北京100050

出　　处：《中国新药杂志》2013年第16期1921-1924,1955,共5页Chinese Journal of New Drugs

摘　　要：固态核磁共振作为一种重要的现代分析研究手段,在许多研究领域都有广泛的用途。本文通过对常用的固态核磁共振技术的介绍,综述了其在药品晶型研究中定性、定量分析的应用,说明固态核磁共振技术是研究晶型的重要方法。As one of modern techniques, solid-state nuclear magnetic resonance （NMR） has been proved very useful in many research fields. Recent advances of solid-state NMR techniques and their applications for quali- tative and quantitative analysis of drug polymorphs were reviewed in this paper. All these applications demonstrate that solid-state NMR is a very unique tool to study the drug polymorphs.

关 键 词：固态核磁共振 药物晶型 应用 质量研究 定性分析 定量分析 综述 

分 类 号：R914.1[医药卫生—药物化学]