牛磺酸对游泳训练诱导大鼠心肌肥厚的影响  

Effects of Taurine on Swimming Exercise-induced Myocardial Hypertrophy in Rats

作　　者：余良主[1] 韩璐[1] 王柏军[1] 丁洁琼[1] 黄碧兰[1] 

机构地区：[1]湖北科技学院基础医学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2013年第3期185-187,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北省教育厅科学技术研究项目(B20122804);湖北科技学院科学研究项目(BK1104;ZX1201)

摘　　要：目的探讨牛磺酸对游泳训练诱导大鼠心肌肥厚的影响。方法采用游泳训练引起的大鼠心肌肥厚为模型。所有大鼠被随机分为3组(每组10只):对照组,游泳组,牛磺酸组。牛磺酸治疗剂量为300 mg.kg-1.d-1。经游泳运动8周后,大鼠处死,分离心脏组织用于检测左心室重/体质量比(LVW/BW),心肌血管紧张素Ⅱ(AngⅡ)含量、转化生长因子β1(TGF-β1)mRNA表达量。结果与正常对照组相比,未给药的游泳组大鼠LVW/BW升高,心肌AngⅡ含量、TGF-β1 mRNA表达量增高;应用牛磺酸治疗则明显减小了游泳训练大鼠LVW/BW,降低了心肌AngⅡ含量、TGF-β1 mRNA表达量。结论牛磺酸治疗可抑制游泳大鼠心肌肥厚的发生,作用机制与其调节心肌组织局部AngⅡ和TGF-β1产生有关。Objective To investigate the effects of taurine on swimming exercise-induced cardiac hyper- trophy. Methods The model of exercise-induced myocardial hypertrophy was established in rats by swimming training method. All rats were randomly divided into three groups, 10 rats in each group：normal control group, swimming training group and taurine treatment group. The swimming training rats were treated with taurine at a dose of 300mg·kg^1 ·d^-1 for 8 weeks. After a 8-week swimming exercise program, all rats were sacrificed and the hearts were clooected to determine left ventricular weight/body weight （LVW/BW）, myocardial angiotensin Ⅱ （ Ang Ⅱ ） level, and transforming growth factor-β1 （ TGF-β1 ） mRNA by RT-PCR. Results Compared with normal control group, the untreated swimming training group exhibited an increase in LVW/BW, Ang Ⅱ level, and TGF-β1 mRNA. Taurine treatment markedly attenuated the increase in LVW/BW, Ang Ⅱ level, and TGF- 61 mRNA in swimming training rats. Conclusion Treatment with taurine could reverse myocardial hypertrophy in swimming training rats,which might be related to its inhibition of angiotensin Ⅱ and TGF-β1production.

关 键 词：游泳 心肌肥大 血管紧张素Ⅱ TGF-Β1 牛磺酸 

分 类 号：R965[医药卫生—药理学]