一氧化氮在家兔缺血再灌注心肌顿抑中的作用及左旋精氨酸干预  

Role of nitric oxide in myocardial stunning after ischemia-reperfusion in rabbits and beneficial effect of L-Arginine

作　　者：王万铁[1] 林丽娜[2] 徐正介[1] 李东[3] 王卫[1] 

机构地区：[1]温州医学院病理生理教研室,温州325003 [2]温州医学院附属第一医院麻醉科 [3]温州医学院分析中心

出　　处：《中国急救医学》2000年第10期576-578,共3页Chinese Journal of Critical Care Medicine

基　　金：浙江省教委科研基金!资助课题 (NO 9716 1)

摘　　要：目的　探讨一氧化氮 (NO)在家兔缺血再灌注心肌顿抑中的作用及左旋精氨酸 (L -Arg)对其影响。方法　 2 0只家兔随机均分为对照组和L -Arg组 ,制备心肌缺血再灌注模型 ,于缺血前、缺血 40分钟及再灌注 2 0分钟取血检测NO水平 ,相应时点监测心功能。结果　心肌缺血再灌注期间 ,NO显著下降 ,心肌舒缩功能明显降低 ,尤以再灌注 2 0分钟为著 ,L -Arg可逆转上述指标。结论　缺血再灌注心肌顿抑与NO水平下降有关 ,LObjective To study the role of nitric oxide (NO) in myocardial stunning after ischemia-reperfusion in rabbits and the beneficial effect of L-Arginine (L-Arg) Methods The rabbits were randomly into two groups:control(I-R+NS,n=10) and L-Arg treated(I-R+L-Arg,n=10),and myocardial ischemia-reperfusion model was established by ligation of left anterior descending coronary.NO content in plasma was measured before ischemia,at 40 minutes after ischemia and 20 minutes after reperfusion,and meanwhile cardial performance was measured at the corresponding time pionts.Results Concentration of NO decreased significantly,and parameters of cardiac function were found to be decreased during myocardial ischemia-reperfusion in I-R+NS group,and more remarkable in 20 minutes after reperfusion;L-Arg reversed the results of mentioned indices as above markedly.Conclusion The reduction of NO during ischemia-reperfusion may contribute to myocardial stunning,L-Arg improves the function of stunned myocardium by raising endogenous NO level.[

关 键 词：一氧化氮 心肌顿抑 左旋精氨酸 心肌缺血 

分 类 号：R363[医药卫生—病理学]