抑郁遗传基础的性别差异  

Gender Differences in the Genetic Underpinning of Depression

作　　者：曹衍淼[1] 王美萍[1] 曹丛[1] 陈光辉[1] 张文新[1] 

机构地区：[1]山东师范大学心理学院,济南250014

出　　处：《心理科学进展》2013年第9期1605-1616,共12页Advances in Psychological Science

基　　金：国家自然科学基金项目(31271105);山东省自然科学基金项目(ZR2010CM006);"十二五"强化建设重点学科(发展与教育心理学)建设经费资助项目;山东师范大学心理学院青年教师研究创新计划项目

摘　　要：人类抑郁有着复杂的遗传基础并存在性别差异。抑郁遗传基础的性别差异主要表现在遗传的直接效应及遗传与环境的交互效应两个方面。本文在回顾、梳理既有抑郁遗传基础性别差异相关研究的基础上,进一步探讨了性激素、个体环境敏感性和中间表型在性别差异形成中的作用。未来该领域应关注遗传对抑郁的动态影响,进一步探讨多基因交互作用、不同类型与性质的环境指标与抑郁遗传基础性别差异的关联。Human depression has complex genetic underpinnings which vary across genders. These gender differences exist both in forms of direct effects of genes and gene-environment interactions on depression. The present paper systematically reviewed the extant literature of both twin studies and molecular genetic studies in the realm and discussed the possible causes of gender differences in the association between genetic variants and depression. Possible explanations provided included gender differences in sex hormones, sensitivity to environment and intermediate phenotype. Previous studies have highligted the value in taking a developmental perspective in investigating genetic effects on depression, future research should employ longitudinal design to reveal the developmental changes of the effect of genetic variants and their interactions with enviroment on depression. Besides, gender differences in genetic susceptibility to depression remain an important direction for future research.

关 键 词：抑郁 遗传 环境 性别差异 

分 类 号：B845[哲学宗教—心理学]