事件相关电位N270对脑梗死患者认知功能的评价  

Value of the event-related potentials N270 on cognitive impairment after cerebral infarction asymptomatic

作　　者：苏滑[1] 刘恒方[1] 周丽丹[1] 高灵利[1] 吴世陶[1] 

机构地区：[1]郑州大学第五附属医院,郑州450052

出　　处：《中国实用神经疾病杂志》2013年第2期18-20,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的通过对脑梗死后无临床症状认知障碍患者和年龄匹配的健康对照者视觉P300和N270的潜伏期和波幅进行检查,以调查N270作为临床检查方法来评估脑卒中后患者认知状态的可行性。方法具有相同形状(匹配条件)或不同形状(冲突条件)的刺激对随机出现给受试者。每对由两个连续的刺激(S1和S2)组成,历时300ms;它们之间出现的间隔时间是700ms。受试者需要在匹配条件下按下一个按钮,并在冲突条件下按下另一个按钮。同时记录他们头皮电极的事件相关电位(ERP)。结果无论是对照组还是观察组,N270是在冲突条件下诱发的第二个刺激(S2)。观察组N270表现出比对照组波幅降低和峰潜伏期延迟。结论 N270可能是检测脑梗死后无临床症状痴呆患者认知功能障碍的一个有效指标。Objective To investigate the value of the event-related potentials N270 on asymptomatic cognitive impairment after cerebral infarction.Methods Thirty patients with cerebral infarction and thirty normal healthy people were studied.The same shapes（match condition） or different shapes（conflict condition） stimulation of were randomly given to the subjects.Each pair was consisted of two successive stimuli（S1 and S2）,which lasted 300 ms,the interval was 700 ms.The subjects were required to press a button on match condition and in the conflict condition press another button.At the same time,scalp electrode of the event-related potentials（ERP） was recorded.Results Either control group or test group,N270 was in conflict conditions induced by the second stimulate（S2）.N270 ERPs in the test group was significantly lower than that in the control group,and the latencies were significantly longer.Conclusion N270 may be an effective indicator to evaluate the asymptomatic cognitive impairment after cerebral infarction.

关 键 词：N270 脑梗死 无症状认知障碍 

分 类 号：R743.33[医药卫生—神经病学与精神病学]