雌激素治疗对蛛网膜下腔出血后脑血管痉挛的影响  

Effects of estrogen treatment on vasospasm after subarachnoid hemorrhage

作　　者：谢礼华 许燕凯[2] 郭芹香[3] 胡毅 李新桂 陈树歆 杨为民 

机构地区：[1]汕头市龙湖区第二人民医院-珠池医院,广东汕头510080 [2]汕头大学医学院附属第一医院 [3]汕头市中心医院 [4]汕头市金平区人民医院 [5]汕头市潮阳区大峰医院

出　　处：《中国伤残医学》2013年第8期70-71,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨雌激素治疗对蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的影响及疗效。方法:随机将120例SAH分为2组各60例,2组均在常规治疗外给予尼莫通治疗,观察组另每天给予2mg雌激素肌肉注射。结果:治疗后2组GCS评分均显著升高(P<0.05),且观察组升高更为明显(P<0.05);观察组CVS发生率明显低于对照组组(x^2=5。14,P<0.05);观察组治疗总有效率为91.7%(55/60),明显高于对照组78.3%(47/60)(x^2=4.18,P<0.05)。结论:雌激素联合尼莫通可明显减少SAH后CVS的发生率,雌激素对蛛网膜下腔出血后脑血管痉挛具有重要防治意义。Objective： To investigate the effects and efficacy of estrogen in the treatment of cerebral vasospasm （CVS） after subarachnoid hemorrhage（SAH）. Methods： 120 patients with SAH were randomly divided into 2 groups,60 cases in each group. Patients in two groups were given conventional treatment and nimotop treatment, patients in the observation group were given daily intramuscular injection of 2mg estrogen. Results： GCS score was significantly higher in the two groups betweent before and after treatment （ P 〈 0.05 ）, and GCS score in the observation group increased more significantly compared with that in the control group （ P 〈 0.05 ）. The incidence rate of CVS in the observation group were significantly lower than that in the control group （X^2 = 5.14, P 〈 0.05 ）. Total effective rate in the observation group was 91.7% （55/60）, significantly higher than 78.3 % （47/60） in the control group （X^2 = 4.18, P 〈 0.05 ）. Conclusion： Estrogen with nimotop could significantly reduce the incidence of CVS after SAH. It has important prevention significance.

关 键 词：蛛网膜下腔出血 脑血管痉挛 雌激素 尼莫通 

分 类 号：R743[医药卫生—神经病学与精神病学]