云南彝族酒精依赖综合征与ALDH2基因多态性的关联研究  

ASSOCIATION OF ALDH2 GENE WITH ALCOHOL DEPENDENCE SYNDROME IN YUNNAN YI POPULATION

作　　者：李金华[1] 景强[1] 赵丽娟[1] 杨浩[1] 钟树荣[1] 胡利平[1] 

机构地区：[1]昆明医科大学法医学院,昆明650500

出　　处：《中国药物依赖性杂志》2013年第4期263-266,291,共5页Chinese Journal of Drug Dependence

基　　金：云南省自然科学基金(2009CD080);国家自然科学基金(81000577;30960115)

摘　　要：目的獉獉:研究乙醛脱氢酶2(ALDH2)基因多态性与云南彝族酒精依赖综合征的相关性。方法獉獉:采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析法,检测云南彝族酒精依赖病例组和健康对照组ALDH2的等位基因和基因型。结果獉獉:在云南彝族酒精依赖患者组和健康对照组中只检测到ALDH2*1一种等位基因,其基因型均为纯合子ALDH2*1/*1。通过与本课题前期研究的云南汉族比较,发现云南彝族人群的ALDH2*1/*1基因型频率和ALDH2*1等位基因频率均高于云南汉族,差异有统计学意义(P<0.001)。结论獉獉:云南彝族人群携带有高酶活性的ALDH2*1等位基因。云南彝族酒精依赖综合征的发病与ALDH2基因有关。Objective： To explore the association between the polymorphism of actaldenhyde dehydrogenase 2 （ALDH2）gene and the alcohol dependent syndrome in Yunnan Yi population. Metho.ds... ： The polymerase chain reaction - restriction fragment length polymorphism （ PCR - RFLP） analysis was used to genotype the ALDH2 gene and its allele between the alcohol dependent group and the control group in Yunnan Yi population. Resu/~：Only one allele ALDH2 ＊ 1 and one genotype ALDH2 ＊ 1/＊ 1 were found between the alcohol dependent group and the control group in Yunnan Yi population. The following results were indicated by comparing the genotype of this study with that of a previous one. The frequencies of both the genotype ALDH2 ＊ 1/＊ 1 and the allele ALDH2 ＊ 1 were much higher in Yunnan Yi population than that in Yunnan Han population. The difference was statistically significant （P 〈 O. 001 ）. Conclusion： ALDH2 ＊ 1 was a high enzyme activity allele in Yunnan Yi population. The actaldenhyde dehydrogenase 2 （ALDH2） gene might be related to the occurrence of alcohol dependent syndrome in Yunnan Yi population.

关 键 词：酒精依赖 ALDH2 云南彝族 

分 类 号：R595.6[医药卫生—内科学]