药物代谢酶的表观遗传调控机制研究进展  

Development of Research on Regulation Mechanism of Epigenetic Modifications for Drug Metabolic Enzymes

作　　者：杨子钊[1] 于琴琴[1] 余露山[1] 孙红颖[1] 曾苏[1] 

机构地区：[1]浙江大学药学院药物分析与药物代谢研究室,杭州310058

出　　处：《中国药学杂志》2013年第17期1425-1428,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81273579);高等学校博士学科点专项科研基金资助项目(20110101130015)

摘　　要：目的对当前表观遗传修饰(如DNA甲基化、组蛋白修饰,染色质重塑、非编码RNA干预等)调控下药物代谢酶基因表达与底物代谢异常的相关研究进行综述。方法笔者综述近年来药物代谢酶表观遗传修饰与催化底物代谢水平调控的研究进展。结果与结论为临床治疗确定生物标志物,并为肿瘤等疾病的治疗提供参考依据。OBJECTIVE To make a review of nowadays related dissertations about epigenetic modifications （ DNA methyla- tion,histone modifications, chromatin remodeling and the non-coding microRNA interruption, etc. ） mediating the abnormal ex- pression of drug metabolic enzymes and inactive metabolism of substances in organisms. METHODS Researches on epigenetic modifications regulating the genes expression or activity change of drug metabolism enzymes were reviewed. RESULTS AND CONCLUSION The research in this field can provide reference for determining biomarkers in clinical diagnosis and therapies of tumors.

关 键 词：药物代谢酶 表观遗传修饰 底物代谢 疾病预防 

分 类 号：R917[医药卫生—药物分析学]