早产儿早期输注高剂量氨基酸对改善早产儿住院期间营养状况分析  

Analysis on improvement effect of early infusion of high-dose amino acid on nutritional status of premature infants during hospitalization

作　　者：江东霞 王永富[1] 

机构地区：[1]贵州省湄潭县人民医院儿科,564100

出　　处：《中国妇幼保健》2013年第25期4169-4172,共4页Maternal and Child Health Care of China

基　　金：贵州省自然科学基金〔200623350〕

摘　　要：目的：探讨早产儿住院期间输注高剂量氨基酸对其营养状况改善的效果，并对其安全性及有效性进行伴价。方法：选取该院2012年1～12月出生体重为1000-2000g的早产儿118例为研究对象，根据患者静脉营养治疗的情况将其分为高剂量组（HP）42例，并于患儿出生后24h给予剂量为3g·kg^-1·d^-1高剂量氨基酸静脉注射，中剂量组（MP）38例，患儿出生后24h内给予剂量为2g·kg^-1·d^-1，低剂量（LP）组38例，患者于出生后24h内给予1g·kg^-1·d^-1的氨基酸静脉注射，对比分析3组患儿体重下降百分比、体重恢复时间、血液学指标变化、静脉注射1周后营养状况。结果：与MP、LP相比，HP患儿体重下降百分比、体重恢复时间、平均住院时间显著减少，差异有统计学意义（P〈0．05）。3组患儿血液生化指标检查结果无统计学意义（P〉0．05），治疗1周后，HP组患儿静脉氨基酸摄入量、总蛋白质摄入量、平均液体摄取量显著高于其余两组患儿，差异有统计学意义（P〈0．05）。结论：对早产儿给予早期高剂量氨基酸静脉输注能有效改善患儿营养状况，且安全可靠。Objective: To explore the improvement effect of early infusion of high-dose amino acid on nutritional status of premature infants during hospitalization,evaluate its safety and effectiveness. Methods: A total of 118 premature infants whose birth weight was within 1 000-2 000 g from January to December in 2012 were selected from the hospital as study objects,then they were divided into high-dose group,middle-dose group and low-dose group according to venous nutritional therapy situation; 42 premature infants in high-dose group were treated with intravenous injection of amino acid( 3 g·kg-1·d-1) within 24 hours after birth,38 premature infants in middle-dose group were treated with intravenous injection of amino acid( 2 g·kg-1·d-1) within 24 hours after birth,38 premature infants in low-dose group were treated with intravenous injection of amino acid( 1 g·kg-1·d-1); the percentages of weight decrease,the times for weight return to normal,the changes of haematological indexes and nutritional statuses at one week after intravenous injection in the three groups were compared and analyzed. Results: Compared with middle-dose group and low-dose group,the percentage of weight decrease,the time for weight return to normal,and the mean hospitalization time in high-dose group decreased significantly,there was statistically significant difference( P < 0. 05). There was no statistically significant difference in biochemical indexes among the three groups( P >0. 05); at one week after treatment,the intake of amino acid by intravenous injection,the intake of total protein,and the mean intake of liquid in high-dose group was statistically significantly higher than those in middle-dose group and low-dose group( P < 0. 05). Conclusion: Early infusion of high-dose amino acid can effectively improve the nutritional status of premature infants,which is safe and reliable.

关 键 词：早产儿 静脉营养 氨基酸 

分 类 号：R722.6[医药卫生—儿科]