β-肾上腺受体阻滞剂的水生态毒理学研究进展  

Current Progress in the Aquatic Ecotoxicology of β-adrenergic Receptor Blockers

作　　者：彭祖华[1] 池剑[1] 孙立伟[1] 傅正伟[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,杭州310032

出　　处：《生态毒理学报》2013年第4期494-503,共10页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金(20907044)

摘　　要：β-肾上腺受体阻滞剂是一类治疗心血管疾病的药物,其药理作用是和β-肾上腺受体结合但不使其活化。由于此类化合物在环境水体中的高检出率以及自身所具有的生物活性,近年来有关其对非靶生物的生态毒性效应日益受到关注。在概括了β-受体阻滞剂的使用现状及其在水体环境中的归趋后,重点介绍了此类化合物对鱼类以及其他水生生物的毒性效应。最后,针对目前的研究现状对今后的工作做出展望。β-adrenergic receptor blockers （or β-blockers） as a group of pharmaceuticals are mostly used in the treatment of cardiovascular disorders. The pharmacological mechanism of β-blockers was that they bind to the β-adrenergic receptors and do not cause receptors activation or stimulation. Since the β-blockers are widely detected in the aquatic environment and have biological activity, the ecotoxicological effects of these pharmaceuticals on non-target organisms have received increased attention in recent years. In this article, we generalized the current applications and fates of β-blockers in the aquatic environment, and then focused on the toxic effects of these compounds on fish as well as other aquatic organisms. Finally, based on the current experimental data, the prospects for further researches on the β-blockers were discussed.

关 键 词：药品和个人护理品 环境行为 肾上腺受体 水生生物 风险评价 

分 类 号：X171.5[环境科学与工程—环境科学]