基于因子分析的血管源性轻度认知障碍证候要素提取及分布研究  

Extraction and distribution of vascular mild cognitive impairment syndrome factors based on factor analysis

作　　者：张允岭[1] 陈宝鑫[1] 金香兰[1] 郭蓉娟[1] 陈志刚[1] 郑硕[1] 曹晓岚[2] 陈志强[3] 张玉莲[4] 赵建军[5] 王少杰[6] 侯小兵[7] 傅晨[1] 薛斐然[1] 王红梅[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]山东中医药大学附属医院,济南250011 [3]河北医科大学中医院,石家庄050011 [4]天津中医药大学第二附属医院,天津300150 [5]长春中医药大学第一附属医院,长春130021 [6]北京大学人民医院,北京100044 [7]中国中医科学院望京医院,北京100102

出　　处：《中华中医药杂志》2013年第9期2596-2600,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2008年中医药行业科研专项(No.200807011);2010年中医药行业科研专项(No.201007002);2010年度北京市社区中医药服务科技示范项目;北京市新医药学科群建设项目(No.XK100270569);北京中医药大学创新团队(No.2011-CXTD-23)~~

摘　　要：目的:初步探索血管源性轻度认知障碍的证候要素,为辨证规范的建立提供依据。方法:多中心协作收集血管源性轻度认知障碍病例803例。采用因子分析寻找该疾病的常见证候要素,并统计证候要素分布特点。结果:最终得到6种证候要素,其中气虚比例为25.90%,其后依次为血瘀(18.31%)、痰(16.94%)、阴虚(14.32%)、阳虚(13.57%)、火(10.96%)。涉及的主要脏腑为肾、肝,次要脏腑为心、脾。蒙特利尔认知量表(MoCA)得分高的患者气虚、痰、血瘀较为常见;MoCA得分低的患者气虚、阳虚、血瘀较为常见。MoCA认知功能亚项受损数目与气虚得分呈正相关,相关系数为0.135(P<0.01)。结论:血管源性轻度认知障碍的证候要素以虚为本,以血瘀、痰实为标,并随疾病进展而演变。Objective： To explore the syndrome factors distribution for vascular mild cognitive impairment, in order to provide the evidence for the standardization of syndrome differentation. Methods： 803 cases of vascular mild cognitive impairment were selected from multi-centers. Factor analysis was used to find out the common syndrome factors. Then, the distribution of syndrome factors was summary. Results： The distribution of the 6 syndrome factors were： patients with qi deficiency up to 25.90%, followed by blood stasis （18.31%）, phlegm （16.94%）, yin deficiency （14.32%）, yang deficiency （13.57%）, fire （10.96%）. The main involved organs were the kidney and liver, followed by the heart and spleen. Patients with higher MoCA score manifested commonly as qi deficiency, phlegm, blood stasis. Patients with lower MoCA score manifested commonly as qi deficiency, yang deficiency, blood stasis. There was positively correlation between the number of damaged cognitive function sub-items and qi deficiency score, and the correlation coefficient was 0.135 （P〈0.01）. Conclusion： The syndrome factors of take deficiency as root cause and blood stasis, phlegm camee as symptoms cause and evolved with the progress of the.

关 键 词：血管源性轻度认知障碍 因子分析 证候要素 

分 类 号：R749.1[医药卫生—神经病学与精神病学]