脉冲振荡联合常规肺功能检测在肺癌和COPD中的应用价值  

Application value of impulse oscillometry system combining with normal pulmonary function determination in lung cancer and COPD

作　　者：何约明[1] 李翠梅[1] 郭伟峰[1] 林一苹[1] 庄锡彬[1] 

机构地区：[1]福建医科大学附属泉州第一医院呼吸内科,泉州362000

出　　处：《福建医药杂志》2013年第4期102-105,共4页Fujian Medical Journal

基　　金：泉州市科技计划资助项目(2010Z10)

摘　　要：目的探讨脉冲振荡(IOS)联合常规肺功能测定技术在肺癌和慢性阻塞性肺疾病(COPD)之间的不同临床应用价值。方法选择经病理确诊的肺癌患者67例(周围型组26例、中央型组26例、伴胸腔积液组15例)和COPD患者30例,应用常规肺功能仪和脉冲振荡肺功能仪进行肺功能测定、比较。结果 COPD组与肺癌组各指标组间比较,差异有统计学意义(P<0.05)。COPD组与周围型和伴胸腔积液组肺癌比较,残总百分比即残气容积与肺总量的比值(RV/TLC)、共振频率(Fres)、Fres与预计值比值(Fres/pre)、总气道阻力(R5)明显升高,第1秒用力呼气容积(FEV1)、FEV1与预计值比值(FEV1/pre)、峰流速(PEF)、PEF与预计值比值(PEF/pre)明显降低;COPD组与中央型肺癌比较,Fres、Fres/pre明显升高,FEV1、FEV1/pre、PEF、PEF/pre明显降低。周围型和中央型肺癌组FVC明显高于伴胸腔积液肺癌组,差异有统计学意义(P<0.05);中央型肺癌和伴胸腔积液肺癌组FEV1/pre明显低于周围型肺癌组,差异有统计学意义(P<0.05)。结论 IOS法在判断COPD与各型肺癌肺功能区别上有明显优势,尤以Fres、Fres/pre指标差异最显著。Objective To explore the different clinical value of impulse oscillometry system （IOS） combining with normal pulmonary function determination in diagnosis of lung cancer and chronic obstructive pulmonary disease （COPD）. Methods Hospitalized patients of lung cancer pathologically confirmed 67 cases （26 cases peripheral types, 26 cases central types, 15 ca- ses pleural effusion types, and another 30 cases COPD patients） were selected. Normal lung function detector and impulse oscillometry lung function detector were adopted respectively for lung function determination and comparison. Results The differ- ence between lung cancer cases and COPD cases had statistical significance （P^0.05）. Compared with groups of peripheral lung cancer and pleural effusion, RV/TLC, Fres, Fres/pre, R5 obviously increased, FEV1, FEV1/pre, PEF, PEF/predistinctly reduced in group of COP/）; Compared with groups of central lung cancer, Fres, Fres/pre clearly improved, FEV1 , FEV1/ pre, PEF, PEF/pre visibly decreased in group of COPD. As far as FVC was concerned, both the peripheral and central types were higher than of pleural effusion types, and the difference also was statistically significant （P〈0.05） ; However, FEV1/pre of central and pteural effusion types were lower than of peripheral types, here still exist statistical significance （P〈0.05）. Con- clusions IOS, particularly Fres and Fres/pre has a distinct advantage on the lung function of COPD and different type lung cancer judgment.

关 键 词：脉冲振荡技术 肺功能 肺癌 慢性阻塞性肺疾病 

分 类 号：R734.2[医药卫生—肿瘤]