粒生素对肿瘤病人化疗后白细胞减少和感染的疗效观察  

Curative Effect of Lishengsu on Leukopenia and Infection after Chemotherapy in Tumor Patients

作　　者：杨颖[1] 张钧[1] 

机构地区：[1]北京市第六医院血液科,北京100007

出　　处：《中国实验血液学杂志》2000年第2期126-128,共3页Journal of Experimental Hematology

摘　　要：本研究观察粒生素 (rhG CSF)对肿瘤病人化疗后促进WBC和ANC减少的恢复作用 ,以及控制感染和对口腔溃疡的疗效。 2 0例肿瘤病人化疗后WBC <2 .5× 10 9/L ,ANC <1.5× 10 9/L时每日皮下注射粒生素 15 0 μg ,一般应用 5天 ,或连续注射至WBC ,ANC恢复到正常水平。对照组WBC ,ANC也降到同样水平 ,不用任何细胞因子 ,但骨髓严重受抑时可给予成分输血。在观察期内隔日查血象 ,注意体温 ,口腔粘膜及肺部体征等。粒生素组病人化疗后WBC ,ANC恢复速度明显快于对照组 ,两者均有非常显著性差异 (P <0 .0 1) ,发热时间缩短 ,口腔溃疡愈合快 (P <0 .0 5 )。观察结果表明 ,小剂量短疗程粒生素对肿瘤病人化疗后能有效地升高WBC与ANC水平 ,缩短发热时间 ,加快口腔溃疡愈合速度 ,还能减少支持治疗。To examine the effect of Lishengsu (rhG CSF) on the recovery of leukopenia and control of infections after chemotherapy, twenty tumor patients were observed. When blood WBC decreased to less than 2.5×10 9/L and ANC less than 1.5×10 9/L after chemotherapy, Lishengsu was administered in a dosage of 150?μg/day for 5 days or until WBC and ANC recovered to normal level. The changes of hemogram, body temprature, the signs of oral mucous membrane and lung were examined. The recovery of WBC and ANC in the Lishengsu group was much faster than that in the control group. The difference between the two groups was statistically significant (P< 0.01). The duration of fever was shorter and the healing of oral ulcers was faster in Lishengsu group than that in the control group (P<0.05). The results indicated that Lishengsu in a low dosage and a short administration period could enhance the recovery of WBC and ANC efficiently, shorten the duration of fever, quicken the recovery process of oral ulcers and reduce the needs for supporting treatment in tumor patients after chemotherapy.

关 键 词：RHG-CSF 粒生素 肿瘤 化疗 白细胞减少 感染 

分 类 号：R730.53[医药卫生—肿瘤]