ERCC1、TYMS、RRM1、TUBB3表达与非小细胞肺癌化疗疗效的相关性和意义  

The Relationship of ERCC1,TYMS,RRM1,TUBB3 Expression with Chemotherapeutic Efficacy in Patients with NSCLC and its Significance

作　　者：孟庆雨[1] 王述民[1] 许世广[1] 童向东[1] 王阁浜[1] 丁仁泉[1] 张大坤[1] 

机构地区：[1]沈阳军区总医院,辽宁沈阳110016

出　　处：《中国肿瘤》2013年第8期661-665,共5页China Cancer

摘　　要：[目的]探讨非小细胞肺癌(NSCLC)术后标本中ERCC1、TYMS、RRM1、TUBB3表达与化疗疗效的相关性。[方法]回顾性分析我院病理确诊的72例NSCLC患者手术切除的肿瘤标本,通过分支DNA-液相芯片法,检测ERCC1、TYMS、RRM1、TUBB3基因mRNA表达水平。[结果]ERCC1、TYMS、RRM1、TUBB3阳性表达率分别为38.9%(28/72)、62.5%(45/72)、55.6%(46/72)和47.2%(34/72);4者表达与年龄、性别、吸烟、组织学类型、TNM分期、淋巴结转移均无关(P>0.05),TYMS、TUBB3在高、中分化组中的阳性表达率显著低于低分化组(P=0.003,P<0.001)。ERCC1、TYMS、RRM1和TUBB3阳性表达的化疗患者1年生存率均显著低于阴性表达者(61.5%vs95.5%,P=0.048;53.5%vs94.9%,P=0.035;58.6%vs92.9%,P=0.039;47.8%vs97.4%,P=0.014)。[结论]ERCC1、TYMS、RRM1、TUBB3阴性表达者化疗生存率高。ERCC1、TYMS、RRM1、TUBB3阴性表达可作为NSCLC患者临床化疗受益的指标。[Purpose] To investigate the relationship of the expression of ERCC1,TYMS,RRM1 and TUBB3 with chemotherapeutic efficacy in patients with NSCLC postoperation.[Methods] Seventy-two cases with NSCLC pathologically proven were analyzed retrospectively. The mRNA expressions of ERCC1,TYMS,RRM1 and TUBB3 gene were detected by branches DNA-liquid chip method. [Results] The positive rate of ERCC1,TYMS,RRM1and TUBB3 was 38.9%（28/72）,62.5%（45/72）,55.6%（40/72） and 47.2%（34/72） respectively.The expression of them were not related to age,gender,smoking,histological type,TNM stage and lymph nodes metastasis（P0.05）. The positive rate of TYMS,TUBB3 in high and moderate differentiation group was lower than those in low differentiation group（P=0.003,P0.001）.The 1-year survival in patients with ERCC1,TYMS,RRM1and TUBB3 positive expression was significantly lesser than that in patients with negative expression （95.5% vs 61.5%,P=0.048;94.9% vs 53.5%,P=0.035;92.9% vs 58.6%,P=0.039;97.4% vs 47.8%,P=0.014）.[Conclusions] The survival is high in NSCLC patients undergoing chemotherapy with ERCC1,TYMS,RRM1and TUBB3 negative expression. The negative expression of ERCC1,TYMS,RRM1 and TUBB3 may be the indicators for patients benefits from chemotherapy.

关 键 词：非小细胞肺癌 疗效 ERCC1 TYMS RRM1 TUBB3 化疗 

分 类 号：R734.2[医药卫生—肿瘤]