结直肠癌患者奥沙利铂过敏反应的临床分析  

Clinical Analysis of Hypersensitivity Reaction to Oxaliplatin in Patients with Colorectal Cancer

作　　者：沈玉萍[1] 刘希[1] 钱红[1] 邱慧敏[1] 茅伟[1] 许青[1] 

机构地区：[1]同济大学附属第十人民医院,上海200072

出　　处：《肿瘤学杂志》2013年第8期623-627,共5页Journal of Chinese Oncology

基　　金：上海市科学技术委员会科研计划项目课题(11411950602)

摘　　要：[目的]研究结直肠癌患者使用奥沙利铂后出现过敏反应的特点,分析结直肠癌患者发生过敏反应的危险因素。[方法]回顾性收集139例采用奥沙利铂化疗的结直肠癌患者的临床资料,分析奥沙利铂过敏反应的发生特征及危险因素。[结果]139例结直肠癌患者接受奥沙利铂静脉化疗,14例(10.07%)患者发生过敏反应。过敏反应以一般症状和皮肤症状多见,主要表现为颜面潮红、皮疹、胸闷气急、心悸等。Logistic回归分析显示接受奥沙利铂姑息化疗的患者更容易发生过敏反应(OR=5.186,95%CI:1.240～21.697)。化疗次数大于6次的患者较化疗次数≤6次的患者发生过敏反应的风险增高(OR=4.130,95%CI:1.132～15.073)。[结论]10.07%的接受奥沙利铂化疗的结直肠癌患者发生过敏反应,过敏反应症状一般较轻,主要表现为皮肤潮红和皮疹。接受奥沙利铂化疗次数6次以上及以姑息化疗为目的的患者较容易发生过敏反应。[Purpose] To evaluate the prevalence and risk factors of hypersensitivity reaction to oxaliplatin in patients with colorectal cancer. [Methods ] A retrospective study was performed on the clinical records of 139 patients with colorectal cancer in The Tenth People＇s Hospital of Shanghai. The prevalence and risk factors for hypersensitivity reaction to oxaliplatin were ob- served and analyzed. [Resuhsl Of 139 colorectal cancer patients received oxaliplatin,14 pa- tients （10.07%） occurred hypersensitivity reactions. Most patients manifested with erythema and rash,which were usually mild. Hypersensitivity correlated with the methods of chemotherapy and the number of chemotherapy cycles. [ Conclusions ~ The prevalence of hypersensitivity reac- tion is 10.07% ,most symptoms are mild and cutaneous. The methods of chemotherapy and the number of chemotherapy cycles could be the predictors for hypersensitivity reactions to oxaliplatin.

关 键 词：奥沙利铂 过敏反应 结直肠肿瘤 

分 类 号：R735.35[医药卫生—肿瘤]