心境障碍与下丘脑-垂体-性腺轴的关系  

Relationship between mood disorder and hypothalamic-pituitary-gonadal axis

作　　者：蓝晓嫦[1] 钟潇琦[1] 周永梅[1] 苗国栋[1] 简炜颖[1] 梁卉薇[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《临床精神医学杂志》2013年第4期235-237,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨心境障碍与下丘脑-垂体-性腺轴的关系。方法:对136例心境障碍患者(抑郁组66例,躁狂组70例)以及与之性别、年龄匹配的正常对照者66人进行血清催乳素(PRL)、雌二醇(E2)、睾酮(T)、促卵泡刺激素(FSH)、促黄体生成素(LH)、孕酮(PRG)水平检测并比较。结果:与正常对照组比较,抑郁组血清PRL水平显著升高(P<0.05);躁狂组血清PRL、T、E2、LH、PRG水平显著升高(P均<0.05)。结论:心境障碍患者存在下丘脑-垂体-性腺轴功能紊乱。Objective：To explore the relationship between mood disorder and hypothalamic-pituitary-gonadal axis.Method：One hundred and thirty-six patients with mood disorder （including 66 cases with depressive and 70 cases with manic） and 66 gender-and age-matched normal controls were recruited and the serum levels of prolactin （PRL）,estradiol （E2）,testosterone （T）,follicle stimulating hormone （FSH）,luteinizing hormone （LH） and progesterone （PRG） were tested.The results were compared.Results：Compared with the normal control group,the serum level of PRL in the depressive group was increased significantly（P0.05）;the serum levels of PRL,T,E2,LH and PRG in the manic group were increased significantly（all P0.05）.Conclusion：Patients with mood disorder have dysfunctional hypothalamic-pituitary-gonadal axis.

关 键 词：心境障碍 躁狂 抑郁 性腺轴 

分 类 号：R749.4[医药卫生—神经病学与精神病学]